Intracellular calcium and blood pressure: Comparison between primary hyperparathyroidism and essential hypertension

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dc.contributor.authorFardella, C
dc.contributor.authorRodriguezPortales, JA
dc.date.accessioned2025-01-21T01:34:18Z
dc.date.available2025-01-21T01:34:18Z
dc.date.issued1995
dc.description.abstractIntracellular calcium has been reported to be increased in essential hypertension, and thought to play a role in its genesis through facilitation of vascular smooth muscle contraction, Since hypertension is more prevalent in primary hyperparathyroidism, intracellular calcium may also be increased in this condition, To investigate whether the hyperparathyroid condition, i.e., hypercalcemia and increased PTH per se, could be associated with high intracellular calcium, we measured intracellular calcium in platelets with the Quin-2 AM fluorometric method in 11 normotensive patients with primary hyperparathyroidism, 15 patients with essential hypertension, and 18 normal controls, all matched for age and sex. We repeated the measurements in 9 of the hyperparathyroid patients after successful surgery, We found that intracellular calcium was higher in normotensive patients with primary hyperparathyroidism than in normal controls (198 +/- 24 vs 113 +/- 11 nM, p < 0.05), but lower than in patients with essential hypertension (198 +/- 24 vs 286 +/- 38 nM, p < 0.05). Successful removal of a parathyroid adenoma decreased intracellular calcium from 215 +/- 22 to 116 +/- 19 nM, (p < 0.01), In the patients with primary. hyperparathyroidism, intracellular calcium was strongly correlated with the levels of PTH (r = 0.87, p < 0.01), but not with the total serum calcium levels (r = 0.04, NS). The decrease in intracellular calcium after parathyroidectomy was also strongly correlated with the decrease in PTH (r = 0.84, p < 0.01), but not with the decrease in total serum calcium (r = 0.16, NS). In the patients with essential hypertension, intracellular calcium correlated well with systolic (r = 0.69, p < 0.01), diastolic (r = 0.76, p < 0.01) and especially mean arterial pressure (r = 0.86, p < 0.01), There was no correlation between blood pressure and intracellular calcium in the patients with primary hyperparathyroidism. We conclude that normotensive patients with primary hyperparathyroidism, as well as patients with essential hypertension, can have increased concentrations of intracellular calcium in platelets. The correction of the hyperparathyroid condition normalizes intracellular calcium concentration. The dose correlation between PTH and intracellular calcium suggests that PTH may act as a ionophore for calcium entry into cells, Whether the increased levels of intracellular calcium may reflect a pre-hypertensive condition in normotensive patients with primary hyperparathyroidism remains to be determined.
dc.fuente.origenWOS
dc.identifier.issn0391-4097
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97541
dc.identifier.wosidWOS:A1995TV75300002
dc.issue.numero11
dc.language.isoen
dc.pagina.final832
dc.pagina.inicio827
dc.revistaJournal of endocrinological investigation
dc.rightsacceso restringido
dc.subjecthypertension
dc.subjecthyperparathyroidism
dc.subjectintracellular calcium
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntracellular calcium and blood pressure: Comparison between primary hyperparathyroidism and essential hypertension
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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