Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor

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dc.contributor.authorCardenas, Ingrid
dc.contributor.authorMeans, Robert E.
dc.contributor.authorAldo, Paulomi
dc.contributor.authorKoga, Kaori
dc.contributor.authorLang, Sabine M.
dc.contributor.authorBooth, Carmen
dc.contributor.authorManzur, Alejandro
dc.contributor.authorOyarzun, Enrique
dc.contributor.authorRomero, Roberto
dc.contributor.authorMor, Gil
dc.date.accessioned2024-01-10T14:22:25Z
dc.date.available2024-01-10T14:22:25Z
dc.date.issued2010
dc.description.abstractPandemics pose a more significant threat to pregnant women than to the nonpregnant population and may have a detrimental effect on the well being of the fetus. We have developed an animal model to evaluate the consequences of a viral infection characterized by lack of fetal transmission. The experiments described in this work show that viral infection of the placenta can elicit a fetal inflammatory response that, in turn, can cause organ damage and potentially downstream developmental deficiencies. Furthermore, we demonstrate that viral infection of the placenta may sensitize the pregnant mother to bacterial products and promote preterm labor. It is critical to take into consideration the fact that during pregnancy it is not only the maternal immune system responding, but also the fetal/placental unit. Our results further support the immunological role of the placenta and the fetus affecting the global response of the mother to microbial infections. This is relevant for making decisions associated with treatment and prevention during pandemics. The Journal of Immunology, 2010, 185: 1248-1257.
dc.description.funderNational Institutes of Health
dc.description.funderEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4049/jimmunol.1000289
dc.identifier.eissn1550-6606
dc.identifier.issn0022-1767
dc.identifier.pubmedidMEDLINE:20554966
dc.identifier.urihttps://doi.org/10.4049/jimmunol.1000289
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79931
dc.identifier.wosidWOS:000279675200054
dc.information.autorucMedicina;Manzur A;S/I;57590
dc.information.autorucMedicina;Oyarzún E;S/I;54261
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1257
dc.pagina.inicio1248
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.revistaJOURNAL OF IMMUNOLOGY
dc.rightsregistro bibliográfico
dc.subjectTOLL-LIKE RECEPTORS
dc.subjectDOUBLE-STRANDED-RNA
dc.subjectNF-KAPPA-B
dc.subjectMURINE GAMMAHERPESVIRUS-68
dc.subjectTROPHOBLAST RESPONSES
dc.subjectADENOASSOCIATED VIRUS
dc.subjectCELLS
dc.subjectTRANSMISSION
dc.subjectPREGNANCY
dc.subjectACTIVATION
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleViral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
dc.typeartículo
dc.volumen185
sipa.codpersvinculados57590
sipa.codpersvinculados54261
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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