DO AXONS GROW DURING ADULTHOOD - A STUDY OF CALIBER AND MICROTUBULES OF SURAL NERVE AXONS IN YOUNG, MATURE, AND AGING RATS

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dc.contributor.authorSAITUA, F
dc.contributor.authorALVAREZ, J
dc.date.accessioned2025-01-23T19:24:55Z
dc.date.available2025-01-23T19:24:55Z
dc.date.issued1988
dc.description.abstractCalibers and microtubules of sural nerve axons were studied in young (6-week-old), mature (14-week-old), and aging (2-year-old) rats.The mean cross-sectional area of nonmedullated fibers was about 0.50 .mu.m2 (range: 0.47-0.52) in the three age groups. Their caliber spectra were also similar. In contrast, myelinated axons grew from 6.6 to 16.7 .mu.m2between the sixth and 14th week of age. The increase of cross-sectinal area was greater, the greater the initial caliber of axon (range 44-154%). No further change of caliber was observed in the aging rat. The cross-sectional area of nerve allotted per myelinated fiber was 42, 66, and 97 .mu.m2 in young, mature, and aging rats, respectively. The fraction of nerve tissue occupied by the axoplasm, though, did not change substantially; it was 20, 28, and 21%, respectively.The microtubular density of 3-.mu.m myelinated axons had a general average of 21 microtubules/.mu.m2. Differences between groups were not significant. In nonmedullated fibers, the microtubular density decreased as the size of the axon increased. No differences were observed between age groups. We conclude that nonmedullated fibers of the sural nerve stop growing before the sixth week whereas myelinated fibers keep growing until the 14th week of age. The correlation between microtubular content and axonal caliber is a lifelong feature of axons.
dc.fuente.origenWOS
dc.identifier.eissn1096-9861
dc.identifier.issn0021-9967
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99416
dc.identifier.wosidWOS:A1988M325700004
dc.issue.numero2
dc.language.isoen
dc.pagina.final209
dc.pagina.inicio203
dc.revistaJournal of comparative neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDO AXONS GROW DURING ADULTHOOD - A STUDY OF CALIBER AND MICROTUBULES OF SURAL NERVE AXONS IN YOUNG, MATURE, AND AGING RATS
dc.typeartículo
dc.volumen269
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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