Local regulation of the axonal phenotype, a case of merotrophism

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dc.contributor.authorCourt, FA
dc.contributor.authorAlvarez, J
dc.date.accessioned2025-01-21T01:07:14Z
dc.date.available2025-01-21T01:07:14Z
dc.date.issued2005
dc.description.abstractIn this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its 'normal' state. The occurence of ribosomes and messenger RNAs in the axon suggests that exoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.
dc.fuente.origenWOS
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96297
dc.identifier.wosidWOS:000236190300009
dc.issue.numero4
dc.language.isoen
dc.pagina.final374
dc.pagina.inicio365
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectaxon
dc.subjectprotein synthesis
dc.subjectnerve regeneration
dc.subjectSchwann cell
dc.subjectWld(s)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLocal regulation of the axonal phenotype, a case of merotrophism
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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