NERVE REGENERATION IS IMPROVED BY INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND BASIC FIBROBLAST GROWTH-FACTOR (BFGF)

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dc.contributor.authorVERGARA, J
dc.contributor.authorMEDINA, L
dc.contributor.authorMAULEN, J
dc.contributor.authorINESTROSA, NC
dc.contributor.authorALVAREZ, J
dc.date.accessioned2025-01-23T19:21:47Z
dc.date.available2025-01-23T19:21:47Z
dc.date.issued1993
dc.description.abstractIn rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons (+ 24 %) up to day 3 post lesion (PL); (ii) more sprouts at early times; (iii) reduced participation of macrophages in the removal of the degenerating myelin in the first week PL; (iv) restoration of the neuromuscular transmission 2 days earlier; (v) a prolonged relaxation time and a reduced specific tetanic tension at week 3 PL but not at week 7 PL. Other indicators of recovery such as conduction velocity of nerve impulse, muscle weight, specific twitch tension, and time to peak were not affected by bFGF or IGF-I. Results suggest that IGF-I and bFGF affect locally Schwann cells and axons, and also the neuron as a whole, including its trophic function. We conclude that IGF-I and bFGF applied to the nerve, albeit moderately, improve the recovery of the neuromuscular function.
dc.fuente.origenWOS
dc.identifier.issn0922-6028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98869
dc.identifier.wosidWOS:A1993LF62700002
dc.issue.numero3
dc.language.isoen
dc.pagina.final189
dc.pagina.inicio181
dc.revistaRestorative neurology and neuroscience
dc.rightsacceso restringido
dc.subjectSCIATIC NERVE
dc.subjectAXON
dc.subjectMACROPHAGE
dc.subjectDENERVATION
dc.subjectTROPHISM
dc.subjectWALLERIAN DEGENERATION
dc.subjectSCHWANN CELL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNERVE REGENERATION IS IMPROVED BY INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND BASIC FIBROBLAST GROWTH-FACTOR (BFGF)
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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