Browsing by Author "Pincheira, J"

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    Fanconi anemia lymphocytes
    (2001) Pincheira, J; Bravo, M; Santos, MJ; de la Torre, C; López-Sáez, JF
    The high frequency of chromosomal breaks in Fanconi anemia (FA) lymphocytes has been related to the increased oxidative damage shown by these cells,
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    G2 repair and chromosomal damage in lymphocytes from workers occupationally exposed to low-level ionizing radiation
    (1999) Pincheira, J; López, I; Sanhueza, S; Ferruz, P; Navarrete, MH; Santos, MJ; López-Sáez, JF
    The effect of the G(2) repair of chromosomal damage in lymphocytes from workers exposed to low levels of X- or gamma-rays was evaluated, Samples of peripheral blood were collected from 15 radiation workers, 20 subjects working in radiodiagnostics, and 30 healthy control donors.
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    G2 repair in Nijmegen breakage syndrome
    (1998) Pincheira, J; Bravo, M; Santos, MJ
    Lymphocytes from a patient with the Nijmegen breakage syndrome (NBS/NBS) and his parents (NBS/+) have been analyzed to identify possible disturbances in chromosomal G(2) repair. The study included the determination of G(2) duration and the analysis of the chromosomal aberration frequencies in lymphocytes with/without caffeine and cyclohexemide (CHM) treatments during G(2), under control and X-irradiated conditions. Under control conditions, NBS/NBS lymphocytes showed that the basal chromosomal damage as well as the damage detected in G(2), with caffeine treatment, and the G(2) duration were higher than cells from an age-matched control. In X-irradiated NBS/NBS lymphocytes, the basal and G(2) chromosome aberration frequencies were higher than in the controls; however, no significant differences in G(2) duration were detected between these two type of cells.