Browsing by Author "Hidalgo, Alejandro A."
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- ItemInactivation of Glutamine Synthetase-Coding Gene glnA Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in Salmonella enterica Serovar Typhi(2020) Millanao, Ana R.; Mora, Aracely Y.; Saavedra, Claudia P.; Villagra, Nicolas A.; Mora, Guido C.; Hidalgo, Alejandro A.Ciprofloxacin is the choice treatment for infections caused by Salmonella Typhi, however, reduced susceptibility to ciprofloxacin has been reported for this pathogen. Considering the decreased approbation of new antimicrobials and the crisis of resistance, one strategy to combat this problem is to find new targets that enhances the antimicrobial activity for approved antimicrobials. In search of mutants with increased susceptibility to ciprofloxacin; 3,216 EZ-Tn5 transposon mutants of S. Typhi were screened. S. Typhi zxx
- ItemThe carbon source influences the efflux pump-mediated antimicrobial resistance in clinically important Gram-negative bacteria(OXFORD UNIV PRESS, 2012) Villagra, Nicolas A.; Fuentes, Juan A.; Jofre, Matias R.; Hidalgo, Alejandro A.; Garcia, Patricia; Mora, Guido C.Multidrug efflux pumps are proteins known to play an important role in resistance in bacteria. These proteins are located in the inner membrane (IM), together with many other proteins, including inducible permeases that participate in the uptake of non-phosphotransferase system (PTS) carbohydrates (i.e. carbohydrates uptaken by mechanisms other than the PTS). However, lipid bilayer space in the IM is limited. Therefore, we examined whether the overexpression of unrelated IM proteins is able to interfere with the efflux-mediated resistance mechanism, consequently increasing the susceptibility towards different antimicrobial compounds.
- ItemXylose Improves Antibiotic Activity of Chloramphenicol and Tetracycline against K. Pneumoniae and A. Baumannii in a Murine Model of Skin Infection(2018) Hidalgo, Alejandro A.; Arias, Angel J.; Fuentes, Juan A.; García Cañete, Patricia; Mora, Guido C.; Villagra, Nicolas A.