Browsing by Author "Garcia, Paula"

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    Acetylated starch and inulin as encapsulating agents of gallic acid and their release behaviour in a hydrophilic system
    (2012) Robert Canales, Paz Soledad; Garcia, Paula; Reyes, Natalia; Chavez, Jorge; Santos Blanco, José Guillermo
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    Evaluation of mismatch negativity as a marker for language impairment in autism spectrum disorder
    (2020) Green, Heather L.; Shuffrey, Lauren C.; Levinson, Lisa; Shen, Guannan; Avery, Trey; Wagner, Melissa Randazzo; Sepulveda, Dayna Moya; Garcia, Paula; Maddox, Chaille; Garcia, Felicidad; Hassan, Sommer; Froud, Karen
    Background: The identification of an early and objective marker of language impairment in autism spectrum disorder (ASD) has the potential to lead to earlier language intervention for affected children. The mismatch negativity (MMN), a passive auditory evoked potential, offers insight into the brain's ability to direct attention to novel sounds. Since exposure to speech is necessary for learning to map meaning onto phonemes, we predicted slower MMN responses to speech sounds would indicate presence of language impairment in ASD.
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    Recovery of Bioactive Compounds from Pomegranate (Punica granatum L.) Peel Using Pressurized Liquid Extraction
    (2021) Garcia, Paula; Fredes, Carolina; Cea, Ines; Lozano-Sanchez, Jesus; Javier Leyva-Jimenez, Francisco; Robert, Paz; Vergara, Cristina; Jimenez, Paula
    Pressurized liquid extraction (PLE) is a clean and environmentally friendly alternative for the recovery of bioactive compounds from fruit by-products. Herein we focused on PLE for the extraction of bioactive compounds from pomegranate peel using a combination of pressurized water and ethanol. The main aim was to determine the optimal PLE conditions, i.e., ethanol percentage and process temperature, to obtain a pomegranate peel extract (PPE) with maximum total phenolic content (TPC), punicalagin content, and antimicrobial activity (AMA). The experimental design was conducted using a central composite design with axial points. Response surface methodology was applied to optimize the response variables using the desirability function. Multiple response optimization indicated a process temperature of 200 degrees C and ethanol of 77% as optimal conditions. The TPC and the punicalagin content of PPE-PLE obtained under optimal conditions were 164.3 +/- 10.7 mg GAE/g DW and 17 +/- 3.6 mg/g DW, respectively. Our findings support the efficacy of PLE on TPC recovery but not in punicalagin recovery. The AMA against S. aureus was 14 mm. The efficacy of PPE-PLE in food applications must continue to be studied in order to achieve adequate information on its potential for developing new food additives.