Browsing by Author "Ferrer Márquez, Fernando Andrés"

Now showing 1 - 9 of 9
  • Thumbnail Image
    Item
    Cirugía bariátrica previo a embarazo y su impacto en el resultado perinatal; revision de la literatura
    (2016) Ferrer Márquez, Fernando Andrés; Mundaca, Manuel; Ledezma Ledezma, Alejandra; Carvajal C., Jorge A.
  • Thumbnail Image
    Item
    Clinical application of amino-terminal pro-brain natriuretic peptide concentration in amniotic fluid for the prediction of preterm birth in symptomatic women
    (2024) Ferrer Márquez, Fernando Andrés; Astudillo Goic, Rocío Pilar; Carvajal C., Jorge A.
    BACKGROUND: Preterm birth accounts for 60% to 80% of neonatal mortality. Approximately one-third of preterm births are caused by the spontaneous onset of preterm labor. Nevertheless, 70% to 90% of women diagnosed with preterm labor will not deliver within 7 days. Thus, many women will be unnecessarily treated by preterm labor with risk medications. Better tools are needed to categorize women in preterm labor into high or low risk of preterm delivery.OBJECTIVE: This study aimed to evaluate the amino-terminal pro-brain natriuretic peptide concentration in the amniotic fluid as a prognostic test to predict the risk of delivery within 48 hours or 7 days and before 34 0/7 or 37 0/7 weeks of gestation in women in preterm labor.STUDY DESIGN: A total of 102 pregnant women presenting signs and symptoms of spontaneous preterm birth (22 0/7 to 34 0/7 weeks of gestation) were included. Amniotic fluid was obtained by amniocentesis, and amino-terminal pro-brain natriuretic peptide concentration was measured. Below normal concentration was defined as <0.5 multiples of the median of the standard curve according to gestational age. The risk of preterm delivery was estimated according to normal or lower-than-normal amino-terminal pro-brain natriuretic peptide concentrations. The predictive capacity of the test (below normal amino-terminal pro-brain natriuretic peptide concentration) was evaluated to identify spontaneous preterm birth at 48 hours or 7 days from amniocentesis and less than 34 0/7 or 37 0/7 weeks at delivery.RESULTS: For the outcome delivery within 48 hours, lower-than-normal amino-terminal pro-brain natriuretic peptide concentration had 94.6% sensitivity, 73.8% specificity, 96.0% negative predictive value, 3.61 positive likelihood ratio, and 0.07 negative likelihood ratio. For the outcome delivery within 7 days, the test had 93.9% sensitivity, 88.7% specificity, 94.0% negative predictive value, 8.31 positive likelihood ratio, and 0.07 negative likelihood ratio. For the outcomes of spontaneous preterm birth before 34 0/7 and 37 0/7 weeks of gestation, below normal amino-terminal pro-brain natriuretic peptide concentrations had 80.0% sensitivity, 83.0% specificity, 78.0% negative predictive value, 4.70 positive likelihood ratio, and 0.24 negative likelihood ratio and 64.1% sensitivity, 91.7% specificity, 44.0% negative predictive value, 7.70 positive likelihood ratio, and 0.39 negative likelihood ratio, respectively.CONCLUSION: Among patients in spontaneous preterm labor, the detection of lower-than-normal amino-terminal pro-brain natriuretic peptide concentrations (<0.5 multiples of the median) in amniotic fluid has an excellent predictive capacity to identify those patients at low risk of preterm delivery within 48 hours or 7 days.
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Comparison of two identification and susceptibility test kits for Ureaplasma spp and Mycoplasma hominis in amniotic fluid of patients at high risk for intra-amniotic infection
    (2020) Kusanovic, Juan Pedro; Vargas Innocenti, Paula Andrea; Ferrer Márquez, Fernando Andrés; Díaz, F.; Córdova, V.; Martinovic, C.; Valdés, R.; Rosas, A.; Luna Fernández, Daniela Fanny; Silva, P.; Silva, K.; Nilo, M. E.; Silva, M. J.; Espejo, E.; Zambrano, M. A.; García, J.; Parra Lara, L. G.; Escobar, M. F.
  • Thumbnail Image
    Item
    Metabolic effects on lung parenchyma of chronic hypoxia secondary to its extrinsic compression in an animal model of congenital diaphragmatic hernia
    (2024) Ferrer Márquez, Fernando Andrés; Carvajal C., Jorge A.; Pontificia Universidad Católica de Chile. Escuela de Medicina
    Congenital diaphragmatic hernia (CDH) occurs as a consequence of abnormal development of the transverse septum and incomplete closure of the pleuroperitoneal canals that occurs between the 6th and 10th week of gestation, resulting in herniation of the abdominal viscera through the diaphragmatic defect. The incidence of CDH is 1.93/10.000 births in North America, with an overall 45.89% mortality in the first year of life. In other latitudes of the world, it is similar, with a prevalence, for example, in Canada of 3.38 per 10,000 and in Chile of 2.1 per 10,000 live births, with a mortality rate in the first year of life between 45 and 65%. Despite all the advances of the last 20 years in maternal-fetal medicine, neonatology, and pediatric surgery, mortality remains high at 45-65% in CDH patients. In the prenatal period, timely diagnosis and the attempt to classify fetuses with CDH according to their risk of death and prognosis have been a constant challenge in maternalfetal medicine (MFM). Even advanced ventilatory and circulatory support techniques, such as extracorporeal membrane oxygenation (ECMO), used in the neonatal period have not significantly influenced the mortality rate of CDH.
  • Thumbnail Image
    Item
    Normal amino-terminal pro-brain natriuretic peptide (NT-proBNP) values in amniotic fluid
    (2017) Carvajal C., Jorge A.; Ferrer Márquez, Fernando Andrés; Araya, F.; Delpiano, A.
  • Thumbnail Image
    Item
    Resultado de estudio prenatal invasivo para el diagnóstico de aneuploidía en el Hospital Sótero del Río
    (2016) Vargas Innocenti, Paula Andrea; Sepúlveda M., Sebastián; Kusanovic, Juan Pedro; Parra, Zasha; Mellado Sagredo, Cecilia; Pardo, Rosa; Silva, Karla; Díaz, Francisco; Ferrer Márquez, Fernando Andrés; Córdova, Víctor; Valdés, Rafael; Martinovic, Carolina; Salas, Carolina; Cortés, Patricio
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Transabdominal collection of amniotic fluid "sludge" and identification of Candida albicans intra-amniotic infection
    (2018) Kusanovic, Juan Pedro; Romero, Roberto; Martinovic, Carolina; Silva, Karla; Erez, Offer; Maymon, Eli; Diaz, Francisco; Ferrer Márquez, Fernando Andrés; Valdes, Rafael; Cordova, Victor; Vargas Innocenti, Paula Andrea; Elena Nilo, Maria; Le Cerf, Patricio