Browsing by Author "Bravo, M"

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    Fanconi anemia lymphocytes
    (2001) Pincheira, J; Bravo, M; Santos, MJ; de la Torre, C; López-Sáez, JF
    The high frequency of chromosomal breaks in Fanconi anemia (FA) lymphocytes has been related to the increased oxidative damage shown by these cells,
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    G2 repair in Nijmegen breakage syndrome
    (1998) Pincheira, J; Bravo, M; Santos, MJ
    Lymphocytes from a patient with the Nijmegen breakage syndrome (NBS/NBS) and his parents (NBS/+) have been analyzed to identify possible disturbances in chromosomal G(2) repair. The study included the determination of G(2) duration and the analysis of the chromosomal aberration frequencies in lymphocytes with/without caffeine and cyclohexemide (CHM) treatments during G(2), under control and X-irradiated conditions. Under control conditions, NBS/NBS lymphocytes showed that the basal chromosomal damage as well as the damage detected in G(2), with caffeine treatment, and the G(2) duration were higher than cells from an age-matched control. In X-irradiated NBS/NBS lymphocytes, the basal and G(2) chromosome aberration frequencies were higher than in the controls; however, no significant differences in G(2) duration were detected between these two type of cells.
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    The terminally ill patient
    (2000) Bravo, M; Echeverria, C; Goic, A; Kottow, M; Lavados, M; Mosso, L; Perez, M; Quintana, C; Rojas, A; Rosselot, E; Serani, A; Taboada, P; Trejo, C; Soc Med Santiago; NCD Risk Factor Collaboration (NCD-RisC)
    The classification of a patient as terminally ill is based on an expert diagnosis of a severe and irreversible disease and the absence of an effective available treatment, according to present medical knowledge. Terminal diseases must not be confused with severe ones, since the latter may be reversible with an adequate and timely treatment. The physician assumes a great responsibility at the moment of diagnosing a patient as terminally ill. The professional must assume his care until the moment of death. This care must be oriented to the alleviation of symptoms and to provide the best possible quality of life. Also, help must be provided to deal with personal, legal and religious issues that may concern the patient.