Browsing by Author "Aranda, G"

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    A new example of 1α-hydroxylation of drimanic terpenes through combined microbial and chemical processes
    (2001) Aranda, G; Moreno, L; Cortés, M; Prangé, T; Maurs, M; Azerad, R
    Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3 beta -hydroxy derivative, which was then chemically converted to 1 alpha -hydroxy-, 1 alpha ,11 alpha -dihydroxy- and 1 alpha -acetoxy-11 alpha -hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. (C) 2001 Elsevier Science Ltd. All rights reserved.
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    Microbial hydroxylation of natural drimenic lactones
    (PERGAMON-ELSEVIER SCIENCE LTD, 1999) Maurs, M; Azerad, R; Cortes, M; Aranda, G; Delahaye, MB; Ricard, L
    Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3 beta-hydroxy derivatives. From isodrimenin, the known natural 7 alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.
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    Microbiologically-assisted hemisynthesis of 1α-hydroxydrimenol
    (2001) Aranda, G; Cortés, M; Maurs, M; Azerad, R
    The hemisynthesis of 1 alpha -hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3 beta -hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1 alpha, thus generating a new potentially bioactive hydroxylated terpenic compound, Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.
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    Practical and efficient 1 alpha-hydroxylation of 4,4-dimethyl-2-ene derivatives in terpenic series.
    (1997) Aranda, G; BertranneDelahaye, M; Azerad, R; Maurs, M; Cortes, M; Ramirez, H; Vernal, G; Prange, T
    The third part of a triptycal synthesis providing 1 alpha-hydroxy compounds, through microbial hydroxylation in position-3 of terpenoid substrates, followed by dehydration to 4,4-dimethyl-2-ene compounds and subsequent allylic hydroxylation by SeO2/pyridine N-oxide, is described.