Browsing by Author "de Santiago, Pamela R."

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis
    (2021) de Santiago, Pamela R.; Blanco, Alejandro; Morales, Fernanda; Marcelain, Katherine; Harismendy, Olivier; Herrera, Marcela Sjoberg; Armisen, Ricardo
    Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) is upregulated in breast cancer, predicting poor prognosis in patients. A few reports in literature examine ADAR1 and long non-coding RNAs (lncRNAs) interplay in cancer and suggest key roles in cancer-related pathways. This study aimed to investigate whether ADAR1 could alter the expression levels of lncRNAs and explore how those changes are related to breast cancer biology.