Browsing by Author "Zuniga, S"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Pharmacokinetics of ketorolac in children after abdominal surgery
    (DUSTRI-VERLAG DR KARL FEISTLE, 1997) GonzalezMartin, G; Maggio, L; GonzalezSotomayor, J; Zuniga, S
    The pharmacokinetics of 2 doses of intravenous ketorolac (0.5 and 0.9 mg x kg(-1)) were studied in 14 children (age 2 - 8 years). A single dose of the drug was injected into the dorsum vein of one hand. Blood samples were collected at regular time intervals for 6 hours. Serum ketorolac concentrations were assayed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume (Vd(area)), the total clearance (Cl-total), and elimination half-life (t(1/2 beta)) were similar in both groups of children who either received 0.5 or 0.9 mg x kg(-1) of ketorolac. The estimated geometric mean Vd(area), Cl-total, and t(1/2 beta) ratios (95% CI in parentheses) for 0.9 mg x kg(-1): 0.5 mg x kg(-1) were 1.24 (0.82, 1.50), 1.14 (0.88, 1.23), and 1.083 (0.40, 1.81), respectively. The pharmacokinetic parameters found in this study are different from those found by other authors in adult subjects.
  • Thumbnail Image
    Item
    Pharmacokinetics of lysine clonixinate in children in postoperative care
    (DUSTRI-VERLAG DR KARL FEISTLE, 1996) GonzalezMartin, G; Cattan, C; Zuniga, S
    The pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg(-1)) were studied in 10 children (age 4 - 10 years) under postoperative care, A single dose of the drug was injected in a forearm vein, Blood samples were collected at regular intervals for 3 hours. Serum clonixin concentrations (expressed as clonixin) were analyzed using a high pressure liquid chromatography method, Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume was similar in both groups of children (1.288 +/- 0.829 1 and 1. 139 +/- 0.667 1, respectively). There were no differences between the values of total plasma clearance and the administered doses (0.026 +/- 0.017 ml x min(-1) and 0.017 +/- 0.008 ml x min(-1), t = 1.07, p = 0.76), The elimination half-life was longer in children who received 6 mg x kg(-1) (44.26 +/- 6.34 min vs 38.63 +/- 10.93 min) but this difference was not statistically significant (t = 0.99, p < 0.34). The pharmacokinetic parameters calculated in these children were different from those found by other authors in adults and experimental animals.
  • Thumbnail Image
    Item
    Simple intratesticular cysts in children: preoperative sonographic diagnosis and histological correlation
    (SPRINGER VERLAG, 1999) Garcia, CJ; Zuniga, S; Rosenberg, H; Arce, JD; Zuniga, F
    Background. Simple intratesticular cysts are rare in children and have been considered the most uncommon cause of scrotal cystic masses in this age group. The exact etiology of these lesions is still unclear. High-resolution ultrasonography has been proved to be a reliable and accurate imaging modality in the evaluation of scrotal abnormalities in children.