Browsing by Author "Zuniga, A."

Now showing 1 - 4 of 4
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    Correction to: Discriminative Capacity of CT Volumetry to Identify Autonomous Cortisol Secretion in Incidental Adrenal Adenomas
    (2022) Olmos, R.; Mertens, N.; Vaidya, A.; Uslar, T.; Fernandez, P.; Guarda, F.J.; Zuniga, A.; San Francisco, I.; Huete, A.; Baudrand, R.
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    Ileal pouch-anal anastomosis in ulcerative colitis: outcomes, functional results, and quality of life in patients with more than 10-year follow-up
    (SPRINGER, 2020) Carcamo, L.; Miranda, P.; Zuniga, A.; Alexander, E.; Molina, M. E.; Urrejola, G.; Larach, T.; Miguieles, R.; Bellolio, Felipe
    Purpose Ileal pouch-anal anastomosis (IPAA) has become the surgical procedure of choice for patients with ulcerative colitis (UC). IPAA was incorporated into our institution in 1984, and thereafter, more than 200 procedures have been performed. The functional results and morbidity of this surgery have been reported previously. However, long-term functional outcomes and quality of life have not been evaluated. Methods As a cohort study, we identified all consecutive patients who underwent IPAA for UC between 1984 and 2017 and selected those with more than 10-year follow-up. Demographic data, morbidity, and pouch survival information were obtained. Long-term functional results and quality of life were evaluated through an e-mail survey using the oresland score and the Cleveland Global Quality of Life scales, respectively. Results Of 201 patients, 116 met the inclusion criteria. Median follow-up was 20 (10-34) years. Early post-operative complications (30 days) were observed in 19 (16.4%) patients and 66 (56.9%) presented adverse events. The IPAA preservation rate at 10 and 20 years was 96.5% and 93.1%, respectively. Long-term functional scores presented a median of 6 (1-15) points. IPAA function was satisfactory in 11 (20.0%) patients, acceptable in 18 (32.7%), and deficient in 26 (47.3%). The median score for global quality of life was 0.8 (0.23-1.0) points. Conclusion IPAA as treatment for UC meets the expectations of cure of the disease, maintaining adequate long-term intestinal functionality associated with a good quality of life in most patients.
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    New treatment for faecal incontinence using zinc-aluminium ointment: a double-blind randomized trial
    (WILEY-BLACKWELL, 2012) Pinedo, G.; Zarate, A. J.; Inostroza, G.; Meneses, X.; Falloux, E.; Molina, O.; Molina, M. E.; Bellolio, F.; Zuniga, A.
    Aim In a randomized double-blind study the therapeutic effect of a novel zincaluminium ointment was compared with placebo in patients with faecal incontinence.
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    Pattern formation via cell-cell adhesion and contact inhibition of locomotion in active matter
    (2023) Rojas, N. O.; Zuniga, A.; Encina, P. C.
    Cell wetting and dewetting in soft substrates present a collection of non-cohesive and cohesive patterns. Prediction of this wide diversity is of critical importance in order to design experiments with polar active matter under confinement. Although in vivo, cells and the extracellular matrix (ECM) are enfolded by flexible substrates, at experimental realizations, hard boundaries are frequently employed. Here, the elastic forces exerted by the cells and the ECM-between a deformable layer and a solid substrate-allow to recast a continuum model that takes account of heterogeneous exchanges such as cell-substrate adhesion and averaged repolarization due to contact inhibition of locomotion (CIL). Theoretical results show that cell aggregation is enforced as increasing cell-cell adhesion and decreasing CIL strength and exhibit different phases from gaseous states to polar liquids and 3D clusters, in agreement with recent reports. Cell diffusion grows as cell rigidity increases, and reduction of ECM stiffness eases cell aggregation and cluster formation. The findings of this work provide the mechanisms that drive and resist active unstable states and can be used as a predictability tool in cell clustering and cell migration experiments.