Browsing by Author "Zuñiga, A."

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    Electron beam-induced structural transformations of MoO 3 and MoO 3-x crystalline nanostructures
    (2012) Díaz Droguett, Donovan Enrique; Zuñiga, A.; Solorzano, G.; Fuenzalida, V.M.
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    Prognostic factors in de novo metastatic renal cell carcinoma: A report from the latin american renal cancer group
    (American Society of Clinical Oncology, 2021) Abreu, D.; Decia, R.; Carvalhal, G.; Gueglio, G.; Tobia, I.; Garcia, P.; Zuñiga, A.; Meza, L.; Bengio, R.; Scorticati, C.; Castillejos, R.; Rodriguez, F.; Autran, A.M.; Gonzales, C.; Gadu, J.; Nolazco, A.; Ameri, C.; Zampolli, H.; Langenhin, R.; Muguruza, D.; Machado, M.T.; Mingote, P.; Yandian, J.; Clavijo, J.; Nogueira, L.; Clark, O.; Secin, F.; Rovegno, A.; Vilas, A.; Barrios E.; Guimarães, G.; Zequi, S.C.; Glina, S.; Pal, S.K.; Rodriguez, O.; Palou, J.; Spiess, P.; Lara, P.N.; Marston Linehan, W.; Pastore, A.L.
    © 2021 by American Society of Clinical Oncology.PURPOSE To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries.
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    Synchronous bilateral laparoscopic adrenalectomy: Surgical technique and perioperative results of a 13-years’ experienceAdrenalectomía laparoscópica bilateral sincrónica: técnica quirúrgica y resultados perioperatorios en 13 años de experiencia
    (2022) Iglesias, T.G.; Affeld, M.F.; Zuñiga, A.; Olmos, R.; Baudrand, R.F.; San Francisco, I.F.; Baudrand R.F.
    © 2021 AEUIntroduction and objectives: Laparoscopic surgery is the standard approach for the treatment of adrenal glands. Bilateral synchronous adrenalectomy is rarely performed, and evidence about this procedure is limited. Our objective is to report our 13-year experience with synchronous laparoscopic bilateral adrenalectomy, evaluating its feasibility, safety, and perioperative outcomes. Patients and methods: A total of 23 consecutive patients undergoing synchronous bilateral laparoscopic adrenalectomy between 2007 and 2020 in a single academic center were included. Variables evaluated were operative time, estimated blood loss, conversion to open surgery, postoperative complications, mortality, and postoperative length of stay. Results: Mean operative time was 189.3 ± 48.9 min. Mean estimated blood loss was 163.0 ± 201.3 ml. There were no conversions to open surgery. Five patients had postoperative complications, three of those were major. No patient died in the perioperative period. Median postoperative length of stay was three days (range 1-30). At pathology analysis, 15 patients had bilateral adrenal hyperplasia, 2 unilateral adrenal hyperplasia and a contralateral benign tumor, 1 unilateral adrenal hyperplasia and a normal contralateral gland, 1 unilateral adenoma, 3 bilateral pheochromocytomas and 1 bilateral myelolipoma. Conclusion: Synchronous bilateral laparoscopic adrenalectomy is a feasible and safe technique. A multidisciplinary and experienced team involving anesthesiologists and endocrinologists is required.