Browsing by Author "Ziegler, Annemarie"

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    Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert
    (2019) Vicuña, Lucas; Fernández, Mario I.; Vial, Cecilia; Valdebenito, Patricio; Chaparro, Eduardo; Espinoza, Karena; Ziegler, Annemarie; Bustamante, Alberto; Eyheramendy Duerr, Susana
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    Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
    (2017) Graumann, Rebecca; Di Capua, Gabriella A.; Oyarzún Isamitt, Juan Esteban; Vásquez, Marcos A.; Liao, Christine; Brañes Yunusic, Jorge Antonio; Roa, Iván; Casanello Toledo, Paola Cecilia; Corvalán R., Alejandro; Owen, Gareth Ivor; Delgado, Iris; Zangemeister-Wittke, Uwe; Ziegler, Annemarie
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    Teneurin protein family: an emerging role in human tumorigenesis and drug resistance
    (2012) Ziegler, Annemarie; Corvalán Rodríguez, Alejandro; Roa, Iván; Brañes Yunusic, Jorge Antonio; Wollscheid, Bernd
    Using a chemoproteomic strategy, we recently demonstrated the expression of teneurin-2, a transmembrane glycoprotein, in the majority of malignant mesothelioma cell lines. This finding was unexpected since no formally organized evidence existed to implicate teneurins in human malignancy. For this reason, here we provide a comprehensive review on the expression of teneurins in human tumors and cell lines. Current evidence supports the aberrant expression of teneurins in various tumor types, their involvement in cancer-related regulatory networks, and their potential participation in drug resistance. Structural attributes of teneurins could enable the detection of shedded forms in body fluids for clinical applications. (C) 2012 Elsevier Ireland Ltd. All rights reserved.