Browsing by Author "Yu X."

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    GnRH agonist-associated pituitary apoplexy: a case series and review of the literature
    (Academic Press, 2021) Guarda F.J.; Guarda F.J.; Yu X.; Shiraliyeva N.; Haines M.S.; Nachtigall L.B.; Bradbury M.; Saylor P.J.
    © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Purpose: To examine the clinical presentation and longitudinal outcome of Pituitary Apoplexy (PA) after gonadotropin-releasing hormone agonist (GnRHa) in a series of patients and compare to prior reports. Methods: A retrospective chart review was performed on seven patients receiving GnRHa who developed PA. Prior reported cases were analyzed. Results: Six men (median age 72 years) with prostate cancer and one woman (aged 22 years) undergoing oocyte donation presented with PA between 1990 and 2020. Most presented with within 24 h of the first dose, but two developed PA 1 to 5 months after GnRHa initiation. The main clinical manifestations were headache (100%), nausea and vomiting (86%). While no patients had a previously known pituitary tumor, all had imaging demonstrating sellar mass and/or hemorrhage at presentation. Among those surgically treated (5/7), 80% (4/5) of patients had pathologic specimens that stained positive for gonadotropins; the remaining patient’s pathologic specimen was necrotic. At the time of PA, the most common pituitary dysfunction was hypocortisolism. Central adrenal insufficiency and central hypothyroidism were reversible in a subset. Pituitary imaging remained stable. Conclusions: This is the first report of a case series with PA after GnRHa administration with longitudinal follow-up. Although infrequent, PA can be life-threatening and should be suspected among patients receiving GnRHa, with or without a known pituitary adenoma, who develop acute headache, nausea and/or vomiting. Since hypopituitarism was reversible in a subset, ongoing pituitary function testing may be indicated.
  • Thumbnail Image
    Item
    Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults
    (2023) Solmi M.; Fiedorowicz J.; Dragioti E.; Estrade A.; Radua J.; Fusar-Poli P.; Winter S.; Correll C.U.; Thompson T.; Anselmi A.; Cracco C.; Machado A.I.; Estrade N.; Agorastos A.; Bozikas V.P.; Solanes A.; Fortea L.; Fullana M.A.; Tiihonen J.; Cortese S.; Arrondo G.; Gerdle B.; Leisch F.; Vancampfort D.; Thygesen L.C.; Hoffmann S.H.; Aschauer H.; Schlogelhofer M.; Aschauer E.; Schneeberger A.; Huber C.G.; Hasler G.; Sehli J.; Conus P.; Do Cuenod K.Q.; von Kanel R.; Brondino N.; Politi P.; Gorwood P.; Scanferla E.; Krebs M.-O.; Llorca P.-M.; Honciuc M.; Kishimoto T.; Takamiya A.; Kitazawa M.; Kurokawa S.; Tazawa Y.; Rabbani G.; Haque A.; Skonieczna-Zydecka K.; Loniewski I.; Marlicz M.; Brambilla P.; Boscutti A.; Cereda G.; Enrico P.; Ciappolino V.; Favaro A.; Gerunda C.; Zoccante L.; Colizzi M.; Bourgin J.; Kaminski K.; Sowa P.; Moghadasin M.; Seedat S.; Spies G.; Matthews E.; Wells J.; Vassilopoulou E.; Efthymiou D.; Gadelha A.; Costardi C.G.; Fonseca L.; Su K.-P.; Kwon J.S.; Kim M.; Lee T.Y.; Papsuev O.; Movina L.; Mankova D.; Andrlikova E.; Janku K.; Saccon D.; Righi E.; Monaco F.; Croatto G.; Demurtas J.; Veronese N.; Pfennig A.; Bauer M.; Bechdolf A.; Meyer-Lindenberg A.; Kahl K.G.; Domschke K.; Koutsouleris N.; Borgwardt S.; Bitter I.; Czobor P.; Unoka Z.; Balazs J.; Mavridis D.; Tsamakis K.; Tunvirachaisakul C.; Maes M.; Rungnirundorn T.; Supasitthumrong T.; Brunoni A.R.; Polanczyk G.; Aparicio L.V.; Schuch F.B.; Luiz J.M.; Valvassori S.S.; Nordentoft M.; Vendsborg P.; Sartorius N.; Heuss S.; Guinart D.; Kane J.; Rubio J.; Hamilton J.; Sand M.; Koyanagi A.; Andreu-Bernabeu A.; Caceres A.S.J.; Arango C.; Diaz-Caneja C.M.; Gonzalez-Penas J.; Parellada M.; Hidalgo-Mazzei D.; Vieta E.; Verdolini N.; Millan M.J.; Moniuszko-Malinowska A.; Samochowiec J.; Kiszkiel L.; Marlicz W.; Stubbs B.; Firth J.; Sullivan S.; Darcin A.E.; Aksu H.; Dilbaz N.; Noyan O.; De Leo D.; Curtis J.; Berk M.; Teasdale S.; Marx W.; Carvalho A.F.; Ward P.; Rosenbaum S.; Horodnic A.V.; Oprea L.; Turliuc S.; Bolos A.; Alexinschi O.; Ifteni P.; Ciuhodaru T.; Matei V.; Nieman D.H.; Sommer I.; van Os J.; van Amelsvoort T.; Sun C.-F.; Guu T.-W.; Jiao C.; Zhang J.; Fan J.; Zou L.; Chi X.; Yu X.; de Timary P.; van Winkel R.; Ng B.; Pena E.; Arellano R.; Roman R.; Sanchez T.; Morgado P.; Brissos S.; Aizberg O.; Mosina A.; Krinitski D.; Mugisha J.; Sadeghi-Bahmani D.; Brand S.; Sheybani F.; Sadeghi M.; Hadi S.; Errázuriz Concha, Antonia; Crossley Karmelic, Nicolás Andrés; Ristic D.I.; Lopez-Jaramillo C.; Kuttichira P.; Kallivayalil R.A.; Javed A.; Afridi M.I.; James B.; Seb-Akahomen O.J.; Daskalakis J.; Yatham L.N.; Yang L.; Okasha T.; Dahdouh A.; Shin J.I.; Lee J.; Mhalla A.; Gaha L.; Brahim T.; Altynbekov K.; Negay N.; Nurmagambetova S.; Jamei Y.A.; Weiser M.
    The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology “P-score”. Methods: The COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1–4 items (“COH-FIT items”) were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ? 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed. Results: From >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (? = 0.95). Factor structure was consistent across age and sex. Conclusions: COH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.