Browsing by Author "Yamamoto, Kotaro"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    MR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions
    (2023) Fujita, Shohei; Sano, Katsuhiro; Cruz, Gastao; Velasco, Carlos; Kawasaki, Hideo; Fukumura, Yuki; Yoneyama, Masami; Suzuki, Akiyoshi; Yamamoto, Kotaro; Morita, Yuichi; Arai, Takashi; Fukunaga, Issei; Uchida, Wataru; Kamagata, Koji; Abe, Osamu; Kuwatsuru, Ryohei; Saiura, Akio; Ikejima, Kenichi; Botnar, Rene; Prieto, Claudia; Aoki, Shigeki
    Purpose: To evaluate the feasibility of liver MR fingerprinting (MRF) for quantitative characterization and diagnosis of focal liver lesions. Materials and Methods: This single-site, prospective study included 89 participants (mean age, 62 years +/- 15 [SD]; 45 women, 44 men) with various focal liver lesions who underwent MRI between October 2021 and August 2022. The participants underwent routine clinical MRI, non-contrast-enhanced liver MRF, and reference quantitative MRI with a 1.5-T MRI scanner. The bias and repeatability of the MRF measurements were assessed using linear regression, Bland-Altman plots, and coefficients of variation. The diagnostic capability of MRF-derived T1, T2, T2*, proton density fat fraction (PDFF), and a combination of these metrics to distinguish benign from malignant lesions was analyzed according to the area under the receiver operating characteristic curve (AUC). Results: Liver MRF measurements showed moderate to high agreement with reference measurements (intraclass correlation = 0.94, 0.77, 0.45, and 0.61 for T1, T2, T2*, and PDFF, respectively), with underestimation of T2 values (mean bias in lesion = -0.5%, -29%, 5.8%, and -8.2% for T1, T2, T2*, and PDFF, respectively). The median coefficients of variation for repeatability of T1, T2, and T2* values were 2.5% (IQR, 3.6%), 3.1% (IQR, 5.6%), and 6.6% (IQR, 13.9%), respectively. After considering multicollinearity, a combination of MRF measurements showed a high diagnostic performance in differentiating benign from malignant lesions (AUC = 0.92 [95% CI: 0.86, 0.98]). Conclusion: Liver MRF enabled the quantitative characterization of various focal liver lesions in a single breath-hold acquisition.