Browsing by Author "Xu, Lei"
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- ItemSynthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B(2021) Mu, Xu-Yang; Wang, Zhi-Jia; Feng, Bo; Xu, Lei; Gao, Li-Xin; Satheeshkumar, Rajendran; Li, Jia; Zhou, Yu-Bo; Wang, Wen-LongA series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived "green" solvent gamma-valerolactone (GVL) and evaluated for their inhibitory activities against PTP1B, the representative compound 6a displayed an IC50 value of 8.04 +/- 0.71 mu M with 4.34-fold preference over TCPTP. These results provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.