Browsing by Author "Wang, Danni"

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    Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin
    (2022) Rivera, Carlos; Lee, Hun-Goo; Lappala, Anna; Wang, Danni; Noches, Veronica; Olivares-Costa, Montserrat; Sjoberg-Herrera, Marcela; Lee, Jeannie T.; Andres, Maria Estela
    The classical neuronal-gene corepressor RCOR1/CoREST is paradoxically enriched in transcriptionally active chromatin. Here the authors show RCOR1 is recruited during promoter-proximal pausing and negatively regulates the nascent-transcript synthesis. They also show that an RCOR1-LSD1- HDAC1 complex removes lysine acetylation from RNA polymerase II to repress transcription.