Browsing by Author "Villarroel, L"

Now showing 1 - 5 of 5
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    Maternal body composition near term and birth weight
    (LIPPINCOTT WILLIAMS & WILKINS, 1998) Mardones Santander, F; Salazar, G; Rosso, P; Villarroel, L
    Objective: To assess the relative influence of maternal body composition at late gestation on birth weight.
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    Mismatch repair gene expression and genetic instability in testicular germ cell tumor
    (2004) Velasco, A; Riquelme, E; Schultz, M; Wistuba, II; Villarroel, L; Pizarro, J; Berlin, A; Ittmann, M; Koh, MS; Leach, FS
    Human mismatch repair (MMR) genes encode highly conserved interacting proteins that correct replication errors predisposing to hereditary gastrointestinal and genitourinary malignancies. A subset of sporadic genitourinary tumors also exhibits MMR deficiency and can be identified by measuring the frequency of microsatellite instability (MSI) in cancer cell DNA. We investigated expression of the two most commonly mutated MMR genes, MSH2 and MLH1, in sporadic testicular germ cell tumor (GCT) in order to: (1) determine the expression pattern of MSH2 and MLH1 proteins in normal seminiferous tubules and histologically distinct GCT subtypes, (2) correlate MMR gene expression with genetic instability in GCT and (3) develop a panel of molecular markers that can identify genetically distinct subsets of GCT for prognostic assessment.
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    Prevalence of Epstein Barr virus infection in healthy individuals in Santiago, Chile
    (SOC MEDICA SANTIAGO, 1995) Ferres, M; Prado, P; Ovalle, J; Fuentes, R; Villarroel, L; Ferreccio, C; Vial, P
    To study the rate of infection by Epstein Barr virus (EBV) in Santiago, Chile, the prevalence of antibody to the viral capsid antigen (VCA-lgG) was determined in a group of 663 healthy individuals grouped by age and socioeconomic level (SEL). In addition, several risk factors for infection were studied. VCA-lgG was determined by ELISA. The total prevalence was 76,7%. When grouped by age and SEL, 50% of the children from low and medium SEL had been already infected by the age two, compared to 5,9% in the high SEL (p<0.01). However, by age twenty, 90% of the total sample had already specific antibodies to EBV. Age and number of household members were positively associated with the infection. High socioeconomic level represented a delay factor in the acquisition of the virus, (p<0.01). These results show that EBV infection is frequent in Santiago, occurring early in childhood among medium and low SEL. Hence, the classical infectious mononucleosis should be recognized more frequently among adolescents and young adults belonging to high SEL, while the clinical spectrum of associated manifestations different from the typical mononucleosis syndrome should be investigated among these exposed in early age.
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    T235 Variant of the angiotensinogen gene and blood pressure in the Chilean population
    (LIPPINCOTT WILLIAMS & WILKINS, 1998) Fardella, CE; Claverie, X; Vignolo, P; Montero, J; Villarroel, L
    Background The angiotensinogen gene has recently been linked to essential hypertension, A variant within this gene, encoding threonine rather than methionine at amino acid position 235, was associated with essential hypertension, However, results of new studies have not confirmed this association, suggesting that ethnic differences may explain the different results.
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    Urinary kallikrein excretion in the human menstrual cycle, normal pregnancy and lactation
    (PARTHENON PUBLISHING GROUP, 1998) Valdes, G; Corthorn, J; Oyarzun, E; Berrios, C; Foradori, A; Germain, AM; Villarroel, L
    Objectives To evaluate the temporal pattern of active and total urinary kallikrein excretion during the menstrual cycle, pregnancy and lactation, and to associate changes in kallikrein excretion with those of ovarian and placental hormones.