Browsing by Author "Vidal, M."

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    Analysis of apheresis outcomes in a cohort of Chilean patients treated with autologous stem cell transplantation: A single center real-world experience
    (2024) Sarmiento, M.; Salinas, J.; Rojas, P.; Gutierrez, C.; Vidal, M.; Jara, V; Garcia, M. J.; Campbell, M. J.; Flores, Y.; Sandoval, V; Vergara, M.; Palacios, F.; Ocqueteau, M.
    Adequate stem cell harvesting is required for autologous hematopoietic transplantation. In deficient mobilizer patients, the collection of stem cells can be challenging because of the impossibility of achieving satisfactory CD34 cell counts with GCSF + - chemotherapy. Plerixafor is a potent and expensive drug that promotes the release of stem cells from the medullary niche to the peripheral blood and allows satisfactory harvests. We performed a retrospective analysis of 370 patients with myeloma and lymphoma harvested at our institution. 99 % of patients achieved satisfactory apheresis using Plerixafor in 45 %. Satisfactory harvests were obtained in patients mobilized with GCSF or plerixafor. In patients who used plerixafor, it was necessary to perform fewer apheresis procedures (P = 0.05). In multivariate analysis, the only factor that predicted the need for plerixafor was the presence of less than 30,000 CD34 / ul on the day of apheresis (OR 0.3. p < 0.001). Since we adopted the plerixafor protocol guided by CD34 counts, the number of patients with harvest failure has decreased. In conclusion, the rational and standardized use of plerixafor favors satisfactory harvest in patients who require autologous transplantation in South-American patients.
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    Galaxy Clusters in the Line of Sight to Background Quasars. I. Survey Design and Incidence of Mg II Absorbers at Cluster Redshifts
    (2008) Lopez, S.; Barrientos, L. F.; Lira, P.; Padilla, N.; Gilbank, D. G.; Gladders, M. D.; Maza, J.; Tejos, N.; Vidal, M.; Yee, H. K. C.
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    Lymphoma-like lesion of the cervix with monoclonal immunoglobulin heavy chain gene rearrangement in PCR analysis. A case report
    (2012) Zoroquiain Vélez, José Pablo; Vidal, M.; Valbuena Mora, José Rafael
    Resumen La lesión del cérvix es una proliferación linfoide benigna que simula un linfoma B difuso de células grandes, por ello es causa de potencial error diagnóstico. Presentamos el caso de una mujer de 24 años con PAP atípico y conización subsecuente, identificándose una proliferación linfoide atípica. El infiltrado linfoide era polimórfico, con numerosas células grandes entremezcladas, sin necrosis ni esclerosis. El epitelio presentó displasia epitelial moderada. Las células grandes fueron inmunorreactivas para CD20, sin expresión de cadenas ligeras de inmunoglobulinas. La hibridación in situ para el virus de Epstein-Barr resultó positiva en escasas células grandes aisladas. Mediante técnica de PCR, para amplificación de la región FR3 de la cadena pesada de la IgH, se observaron 2 bandas monoclonales. Hasta el último seguimiento (24 meses), no se encontró evidencia de enfermedad sistémica/progresión.
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    Place-of-death preferences among patients with cancer and family caregivers in inpatient and outpatient palliative care
    (2020) Vidal, M.; Rodríguez Núñez, Alfredo; Hui, D.; Allo, J.; Williams, J. L.; Park, M.; Liu, D.; Bruera, E.