Browsing by Author "Vial Claro, Pablo Agustín"

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    Historia natural de la infección por virus de inmunodeficiencia humano en una cohorte de pacientes chilenos
    (1996) Vial Claro, Pablo Agustín; Ferreccio Readi, Catterina; Abarca Villaseca, Katia; Ortiz Neira, Marisol Edith; Noriega Ricalde, Miguel Luis; Pérez Cortés, Carlos; Labarca L., Jaime; Torres H. M.; Ferrés, Marcela; González Wiedmaier, Claudia; Acuña L., Guillermo
    We characterized clinical manifestations and the risk to develop AIDS in a cohort of 32 patients infected with human immunodeficiency virus without AIDS. A multivariate analysis was performed to determine association between the progression of infection and control variables (socioeconomic level, age, sex and sexual preferences) and causal variables (psycho-social changes, significant clinical events, stress scoring and sexual activity). The cumulative AIDS incidence, defined as a CD4 lymphocyte count below 200 cells/cm3 was 50% at 6.5 years and 82% at 8 years. Using clinical criteria to define AIDS, 50% developed the disease at 8 years of follow up. Among studied factors, only age (faster progression at higher age) and time of evolution were associated with progression. In stages before AIDS, the most frequent diseases were acute diarrhea, sexual transmission diseases, oral candidiasis, sinusitis and varicella zoster infections. The reduction of CD4 lymphocytes below 200 cells/cm3 always preceded the symptoms of the disease. Two patients have remained more than eight years without clinical or immunological deterioration.
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    Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en pacientes chilenos
    (2007) Ferrer C., Pablo; Vial Claro, Pablo Agustín; Ferres Garrido, Marcela Viviana; Godoy Mayorga, Paula Carolina; Cuiza Vásquez, Analía; Marco Caceres Claudia Alejandra; Castillo H., Constanza; Umana C., Maria Elena; Rothhammer E., Francisco; Llop R., Elena
    Andes hantavirus (ANDV) infection in Chile has a variable clinical expression, and infected individuals may present with different grades of disease severity. This study aimed to determine if clinical expression of ANDV infection in Chilean patients is associated with the HLA system. HLA alleles A, B, DRB1 and DQB1, were studied in two groups of patients with confirmed ANDV infection: 41 patients with a mild disease course (without respiratory failure and cardiovascular shock) and 46 patients with a severe disease course (with respiratory failure and shock). Molecular typing of HLA system was performed by SSP-PCR. The HLA-DRB1*15 allele, was significantly more common in the group of patients with mild disease (p = 0,007) and thus for possibly associated with a protective effect against ANDV infection. Conversely, HLA-B*08 was more common in patients with severe disease (p = 0,06). Although the association was marginally significant, allele HLA-B*08 may be linked to an increased susceptibility to the severe clinical course of HCPS by ANDV.