Browsing by Author "Valenzuela, R."
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- ItemAdult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation(2019) Krause Leyton, Bernardo; Penaloza, E.; Candia, A.; Canas, D.; Hernandez, C.; Arenas Menéndez, German Alberto; Peralta-Scholz, M.J.; Valenzuela, R.; Garcia-Herrera, C.; Herrera, E.A.
- ItemClinical and Demographical Characteristics of Patients with Medication Overuse Headache in Argentina and Chile: Analysis of the Latin American Section of COMOESTAS Project(2015) Shand, Beatriz; Goicochea, M. T.; Valenzuela, R.; Fadic Ruiz, Ricardo Julio Nicolás; Jensen, R.; Tassorelli, C.; Nappi, G.
- ItemHeme-oxygenase-1 is decreased in circulating monocytes and is associated with impaired phagocytosis and ROS production in lupus nephritis(2019) Cuitino, L.; Obreque Castro, Javiera Constanza; Gajardo Meneses, Patricia; Villarroel, A.; Crisostomo, N.; San Francisco Reyes, Ignacio Felipe; Valenzuela, R.; Mendez Olivieri, Gonzalo Patricio; Llanos Muñoz, Carolina
- Itemn-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity: Potential relationship with gut microbiota(2021) Zapata, J.; Gallardo, A.; Romero, C.; Valenzuela, R.; Garcia-Diaz, D. F.; Duarte, L.; Bustamante, A.; Gasaly, N.; Gotteland, M.; Echeverría González, Francisca CeciliaBackground: Obesity is a worldwide public health problem characterized by fat tissue accumulation, favouring adipose tissue and metabolic alterations. Increasing energy expenditure (EE) through brown adipose tissue activation and white adipose tissue (WAT) browning has gained relevance as a therapeutic approach. Different bioactive compounds, such as n-3 polyunsaturated fatty acids (PUFA), have been shown to induce those thermogenic effects. This process is regulated by the gut microbiota as well. Nevertheless, obesity is characterized by gut microbiota dysbiosis, which can be restored by weight loss and n-3 PUFA intake, among other factors. Knowledge gap: However, the role of the gut microbiota on the n-3 PUFA effect in inducing thermogenesis in obesity has not been fully elucidated. Objective: This review aims to elucidate the potential implications of this interrelation on WAT browning adiposw sittue (BAT), BAT activity, and EE regulation in obesity models.
- ItemPharmacokinetics of posaconazol in the prophylaxis and treatment of invasive fungal infection in immunocompromised children in a pediatric hospital,Farmacocinética de posaconazol en la profilaxis y tratamiento de la infección fúngica invasora en niños inmunocomprometidos en un hospital pediátrico(2018) Valenzuela, R.; García, P.; Barraza, M.; Palma, J.; Catalán, P.; Santolaya, M.E.; Torres, J.P.; Morales Vallespín, J.
- ItemSerotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 beta-Cells Treated with Palmitate and Oleate(2016) Cataldo Bascuñan, Luis Rodrigo; Busso, Dolores; Olmos Coelho, Pablo Roberto; Galgani Fuentes, José; Valenzuela, R.; Mezzano, D.; Aranda, E.; Cortés Mora, Víctor Antonio; Santos Martín, José Luis