Browsing by Author "VERGARA, JF"

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    ANDROGENS AND EFFECTS OF OPIOIDS AND CATECHOLAMINES ON THE SMOOTH-MUSCLE OF THE RAT VAS-DEFERENS
    (1985) MIRANDA, H; PEREZ, E; FERNANDEZ, E; ROSSELOT, F; VERGARA, JF; WOLSTENHOLME, WW; ZUAZO, A
    In the neuronal electrically stimulated vas deferens of the rat, the responses evoked by morphine, .beta.-endorphin and catecholamines were studied. The tissue was obtained from rats at various times (7-60 days) following castration, adrenalectomy and castration with adrenalectomy. Pharmacological data are presented which verify an increased responsiveness to morphine after castration with or without adrenalectomy. Decreased responsiveness was observed after adrenalectomy alone. Decreased responsiveness of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to .beta.-endorphin was unchanged by this treatment (castration, adrenalectomy), the .epsilon.-opioid receptor may be unaffected by androgens.
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    BIOGENIC-AMINES AND BETA-ENDORPHIN RESPONSES IN THE RAT VAS-DEFERENS
    (1982) MIRANDA, H; VERGARA, JF; ROSSELOT, F; FERNANDEZ, E
    Activation of opioid peptide receptors by .beta.-endorphin results in a change of bioamines in peripheral tissues. The action of .beta.-endorphin on the smooth muscle of the isolated rat vas deferens may be independent of catecholaminergic, cholinergic and tryptaminergic neurotransmission. The action may involve a specific opioid .epsilon.-receptor having a high degree of affinity for .beta.-endorphin.