Browsing by Author "VARGAS, I"

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    ADRENAL AND LIVER PARTICIPATION IN RATS POST-STRESS DIABETIC RESPONSE
    (1976) VARGAS, I; KAWADA, ME
    Sixty minutes of restraint stress, preceded by chlorpromazine administration which stimulates somatotropic hormone secretion (STH), produced an acute post-stress diabetic response (PDR) in normal-intact rats and in adrenalectomized rats. This PDR lasted 3-4 h and was evaluated by glucemia and glucosuria determination and by the appearance of an insulin antagonist, .alpha.2-glycoprotein STH-dependent, called .alpha.2-inhibitor, which inhibits glucose uptake by isolated tissues. When tested in the suprahepatic blood of animals after stress it showed increased activity in normal and in adrenalectomized rats. .alpha.2-Inhibitor may be produced in the liver by the action of STH and without primary glucocorticoid participation. The post-stress hyperglucemic response of adrenalectomized rats had a similar tendency to that of the control, although with initial and final values of glucemia significantly below the control. This response supports the idea that postadrenalectomy gluconeogenesis was evoked during and after the systemic stress.