Browsing by Author "Uribe San Martin, Reinaldo Moisés"

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    Diagnóstico precoz de la enfermedad de Parkinson
    (Sociedad Iberoamericana de Información Científica (SIIC),, 2009) Juri Clavería, Carlos Andrés; Uribe San Martin, Reinaldo Moisés
    Parkinson's disease (PD) is a neurodegenerative disorder clinically characterised by motor symptoms, and these manifestations arise after an extensive loss of dopaminergic neurons in the substantia nigra. In the last decades evidence has emerged to show that the onset of neurodegeneration in PD probably begins many years before the onset of motor symptoms. Additionally nonmotor manifestations, such as olfactory dysfunction, REM behavioural disorder, depression and constipation, also arise earlier than motor manifestations in the course of the disease. Neuroimages are useful in identifying subjects at risk of developing PD, as the result of early non-motor manifestations, or carriers of genetic mutations associated with familial PD. In this article we review the available evidence in diagnosing PD in the early non-motor stage and how this approach could help us to improve the treatment of PD patients
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    Neuromyelitis optica spectrum disorders: Profile of a cohort according to the 2015 diagnostic criteria
    (Revista de Neurologia, 2017) Uribe San Martin, Reinaldo Moisés; Ciampi Diaz, Ethel Leslie; Galilea Izquierdo, Antonia; Sandoval Rubio, Patricio Alberto Mario; Miranda Vera, Héctor David; Mellado Talesnik, Patricio Andrés; Cárcamo Rodríguez, Claudia Andrea; Albornoz Cruz, Juan Pablo; Huete Garin, Isidro Álvaro
    The new 2015 criteria for neuromyelitis optica spectrum disorders (NMOSD) have been recently incorporated in the study of different international cohorts. Aim. To describe clinical-radiological characteristics and prognostic factors in patients with NMOSD according to the 2015 criteria. Patients and methods. Retrospective analysis of 36 patients diagnosed with NMOSD according to serologic AQP4 status (positive, negative, unknown and negative + unknown). Clinical and radiological characteristics were compared and possible disability prognostic factors were evaluated. Results. AQP4 were positive in 7 patients, negative in 12 and unknown in 17. Age of presentation was 36.6 ± 16 years, with higher female proportion (4:1). Mean disease duration was 7.4 ± 7.6 years. Most frequent presenting symptoms were acute myelitis (61%), optic neuritis (33%) and area postrema syndrome (11%). Most frequent MRI lesion was longitudinally extensive transverse myelitis (75%). All patients received acute treatment during attacks, and preventive treatment was used in 81% (azathioprine and rituximab mostly prescribed). Median EDSS was 2.0 at the end of follow-up. No differences were observed in any of the variables comparing serologic status. Age of first attack was prognostic, with direct correlation with EDSS. First attack in < 30 years was protective, meanwhile > 50 years old patients had increased risk of disability. Conclusions. The 2015 criteria allow the description and classification of NMOSD patients within different cohorts. Age of first attack seems to be a prognostic factor for developing disability.