Browsing by Author "Uriarte, Eugenio"

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    New Approaches to 6-Oxoisoaporphine and Tetrahydroisoquinoline Derivatives
    (WILEY-BLACKWELL, 2010) Sobarzo Sanchez, Eduardo; Uriarte, Eugenio; Santana, Lourdes; Tapia, Ricardo A.; Perez Lourido, Paulo
    2,3-Dihydro-6-hydroxy-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, 6-hydroxy-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, and 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-l-yl)benzyl benzoate, easily available by a Bischler-Napieralski cyclization, were used as starting materials to afford 6-oxoisoaporphine and 2,3-dimethoxy-5,6,8,12b-tetrahydroisoindolo[1,2-a]isoquinoline as the main products. However, the catalytic hydrogenation of the benzyl benzoate derivative afforded, under mild conditions, 1,2,3,4-tetrahydro-6.7-dimethoxy-1 -(2-methylphenyl)isoquinoline.
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    New benzimidazolequinones as trypanosomicidal agents
    (2021) Lopez-Lira, Claudia; Tapia, Ricardo A.; Herrera, Alejandra; Lapier, Michel; Maya, Juan D.; Soto-Delgado, Jorge; Oliver, Allen G.; Lappin, A. Graham; Uriarte, Eugenio
    Herein, the design and synthesis of new 2-phenyl(pyridinyl)benzimidazolequinones and their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The compounds were evaluated in vitro against the epimastigotes and trypomastigote forms of Trypanosoma cruzi. The replacing of a benzene moiety in the naphthoquinone system by an imidazole enhanced the trypanosomicidal activity against Trypanosoma cruzi. Three of the tested compounds (11a-c) showed potent trypanosomicidal activity and compound 11a, with IC50 of 0.65 mu M on the trypomastigote form of T. cruzi, proved to be 15 times more active than nifurtimox. Additionally, molecular docking studies indicate that the quinone derivatives 11a-c could have a multitarget profile interacting preferentially with trypanothione reductase and Old Yellow Enzyme.
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    Protective Effect of Synthetic Hydroxycoumarin Derivatives on Bovine Aortic Endothelial Cells Against Oxidative Stress Induced by 3-Morpholinosydnonimine and Hydrogen Peroxide
    (2012) Pérez Cruz, Fernanda R.; Montecinos Escobar, Rodrigo Andrés; Villamena, Frederick A.; Das, Amlan; Uriarte, Eugenio; López Alarcón, Camilo Ignacio; Olea Azar, Claudio