Browsing by Author "Tolotta, Julianna"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
    (2024) Schepps, Samuel; Xu, Jonathan; Yang, Henry; Mandel, Jenna; Mehta, Jaanvi; Tolotta, Julianna; Baker, Nicole; Tekmen, Volkan; Nikbakht, Neda; Fortina, Paolo; Fuentes, Ignacia; Lafleur, Bonnie; Cho, Raymond J.; South, Andrew P.
    Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.