Browsing by Author "Tenorio, Laura"

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    A Latin American survey on demographic aspects of hospitalized, decompensated cirrhotic patients and the resources for their management
    (2020) Vorobioff, Julio D.; Contreras, Fernando; Tanno, Federico; Hernandez, Lucia; Bessone, Fernando; Colombato, Luis; Adi, Jose; Fassio, Eduardo; Felgueres, Mirta; Fernandez, Guillermo; Gaite, Luis; Gibelli, Diana; Gomez Darrichon, Hernan; Lafage, Matias; Lombardo, Daniel; Lopez, Susana; Mateo, Alejandro; Mendizabal, Manuel; Pecoraro, Julieta; Ruf, Andres; Ruiz, Pablo; Severini, Javier; Stieben, Teodoro; Sixto, Marcela; Zarate, Fabian; de la Barra Barraza, Sergio; Donoso Sierra, Irene; Rivas Pacheco, Violeta; Roblero, Juan P.; Rojas, Juan O.; Ruiz Gonzalez, Patricio; San Martin Rodriguez, Diego; Sierralta, Armando; Urzua Manchego, Alvaro; Valdes, Eliana; Yaquich, Pamela; Wolff, Rodrigo; Beltran Valdivia, Flor; Gallegos, Roxana C.; Galloso, Rocio; Marcelo, Julio S.; Montes, Pedro; Tenorio, Laura; Veramendi, Isabel; Alava, Elizabeth; Armijos, Ximena; Benalcazar, Gonzalo; Carrera, Enrique; Pazmino, Galo F.; Marriott Diaz, Eduardo; Garassini, Miguel; Marrero, Rosalia P.; Infante, Mirta; Paez Suarez, Dayron; Gutierrez, Jose C.; Villadoniga Reyes, Carmen M.; Serrano, Yoel M.; Hernandez Hernandez, Rivardo; Martinez Martinez, Orelvis; Perez Gonzalez, Teresita; Andara, Maria T.; Sanchez Hernandez, Marco; Gerona, Solange; Garcia, Ivan; de la Tijera, Fatima; Pessoa Lopez, Edmundo; Torres, Kenia; Garzon, Martin
    Introduction & objectives: Liver cirrhosis is a major cause of mortality worldwide. Adequate diagnosis and treatment of decompensating events requires of both medical skills and updated technical resources. The objectives of this study were to search the demographic profile of hospitalized cirrhotic patients in a group of Latin American hospitals and the availability of expertise/facilities for the diagnosis and therapy of decompensation episodes.
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    Effectiveness of the implementation of a re-linkage to care strategy in patients with Hepatitis C who were lost of follow-up
    (2021) Mendizabal, Manuel; Thompson, Marcos Andres; Ridruejo, Ezequiel; Gonzalez Ballerga, Esteban; Ruiz Velasco, Jose Antonio Velarde; Palazzo, Ana; Mezzano, Gabriel; Muñoz Espinosa, Linda Elsa; Pessoa, Mario; Cerda Reyes, Eira; Soza, Alejandro; Ruiz, Sandro; Gomez-Aldana, Andres Jose; Gerona, Solange; Fuster, Francisco; Anders, Margarita; Beltran Valdivia, Flor De Maria; Poniachik, Jaime; Schinoni, Maria Isabel; Hernandez, Nelia; Montes, Pedro; Girala, Marcos; Castillo, Lida; Castillo-Barradas, Mauricio; Chavez, Rocio; Cabrera, Cecilia; Tenorio, Laura; Zevallos, Katherine; Garavito, Jorge; Brutti, Julia; Tagle, Martin; Castro Narro, Graciela; Vera Pozo, Emilia; Perazzo, Rosalia; Guillermo Toro, Luis; Varon, Adriana; Ferreiro, Melina; Lazcano, Monserrat; Dolores Murga, Maria; Gomez, Fernando; Hernandez, Larissa; Damasio Moutinho, Bruna; Gandara-Calderon, Julian; Vargas Domínguez, José Ignacio; Simian, Daniela; Silva, Marcelo
    Background: In order to achieve the World Health Organization’s ambitious goal of eliminating hepatitis C (HCV), we must implement innovative strategies to diagnose and treat more patients. Therefore, our study aimed to identify patients with chronic HCV infection who lost follow-up and offer them re-linkage to care and treatment with direct-acting antivirals (DAAs). Methods: We conducted an implementation study of a strategy to contact patients with chronic HCV who were not under regular follow-up in 10 countries from Latin America. Patients with HCV were identified by the international classification of diseases (ICD-9/10) or similar. Medical records were then reviewed to confirm the diagnosis of chronic HCV infection defined as anti-HCV + and detectable HCVRNA. Identified patients who were not under follow-up by a liver specialist were contacted to offer them a medical reevaluation and, eventually, treatment with DAA. Results: A total of 3,709 patients were classified as HCV, of which 367 (9.9%) presented undetectable HCVRNA, and 148 (4.0%) were wrongly coded. Overall, 3,194 (86.1%) individuals were identified with chronic HCV infection, 49,9% were male, median age was 61 years (IQR 51-69); 166 (5.2%) developed hepatocellular carcinoma, and 117 (3.7%) underwent liver transplantation. Advanced liver fibrosis (F3-F4) was present in 1,361 (42.6%) patients. A total of 1,764 (55.2%) patients were under close care. Of these, 1,371 (74.7%) received antiviral treatment, 70 (5.3%) did not achieve sustained virologic response, 314 (17.8%) were not treated for different reasons and 133 (7.5%) died. We identified 1,430 (44.8%) patients who were lost of follow-up, 564 (39.4%) of whom were finally located. Of those contacted, 402 (71.3%) were candidates to receive DAAs, 108 (19.2%) were treated in other institutions, 12 (2.1%) did not wish to be treated, and 42 (7.4%) died (Figure). Globally, in our study 786/3,194 (24.6%) patients were candidates to receive antiviral therapies. Conclusion: In our cohort, 1 out of 4 patients with chronic HCV could be re-linked to care and treated. This strategy impresses to be effective, accessible and, significantly impact on the HCV cascade to cure.
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    Latin American Association for the Study of the Liver (ALEH) guidance of preoperative care in liver transplantation: referral criteria, patient assessment, and waiting list management
    (2025) Mainardi, Victoria; Pages, Josefina; Menéndez, Josemaría; Zapata, Rodrigo; Díaz Piga, Luis Antonio; Marciano, Sebastián; Cairo, Fernando; Padilla-Machaca, Martin; Tenorio, Laura; Urzúa, Álvaro; Navarro, Lucía; Domínguez, Nicolás; Coste, Pablo; Mendizábal, Manuel; Martínez, Jorge; López, Sergio; Varón, Adriana; Alfeu de Medeiros Fleck, jr; Abad Gonzáles, Jhon; Restrepo, Juan Carlos; Codes, Liana; Lisboa Bittencourt, Paulo; Pérez Figueroa, Norma Marlene; Castro-Narro, Graciela; Terrabuio, Débora Raquel B.; Pessoa, Mário Guimarães; Girala, Marcos; Schiavon, Leonardo Lucca; Aguilera, Edgard; Valenzuela Aguilera, Kenia; Samada, Marcia; Gerona, Solange; Villamil, Alejandra
    Liver transplantation (LT) is the standard of care therapy for patients with decompensated cirrhosis, early-stage hepatocellular carcinoma, acute liver failure, and other expanding indications. Latin America is a highly heterogeneous region characterized by an uneven distribution of socio-economic conditions and irregular access to health resources, and consequently LT activity varies across it. This current guidance of preoperative care in LT represents a collaborative effort to assess and standardize preoperative evaluation of liver transplant candidates in Latin America. It is the first position paper of the special interest group on LT of the Latin American Association for the Study of the Liver (ALEH), which draws evidence-based comprehensive recommendations regarding who to refer, the LT assessment and how to manage the patient on the waiting list, taking into consideration their applicability in Latin America.