Browsing by Author "Tellez, R"

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    Association of primary antiphospholipid syndrome with primary adrenal insufficiency
    (J RHEUMATOL PUBL CO, 1996) Gonzalez, G; Gutierrez, M; Ortiz, M; Tellez, R; Figueroa, F; Jacobelli, S
    The association of primary adrenal insufficiency with antiphospholipid antibodies is usually reported in the context of adrenal thrombosis or hemorrhage. We describe a 35-year-old woman who developed a primary antiphospholipid syndrome (spontaneous abortion, thrombocytopenia, and cerebrovascular occlusion) in association with primary adrenal insufficiency without evidence of suprarenal hemorrhage or thrombosis.
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    Does perchlorate in drinking water affect thyroid function in newborns or school-age children?
    (2000) Crump, C; Michaud, P; Tellez, R; Reyes, C; Gonzalez, G; Montgomery, EL; Crump, KS; Lobo, G; Becerra, C; Gibbs, JP
    Perchlorate is known to suppress thyroid function by inhibiting uptake of iodide by the human thyroid at doses of 200 mg/day or greater. A study was conducted to investigate the potential effects of perchlorate in drinking water on thyroid function in newborns and school-age children. A total of 162 school-age children and 9784 newborns were studied in three proximate cities in northern Chile that have different concentrations of perchlorate in drinking water: Taltal (100 to 120 mu g/L), Chanaral (5 to 7 mu g/L), and Antofagasta (non-detectable: <4 mu g/L). Among schoolchildren, no difference was found in thyroid-stimulating hormone levels or goiter prevalence among lifelong residents of Taltal or Chanaral compared with those of Antofagasta, after adjusting for age, sex, and urinary iodine. No presumptive cases of congenital hypothyroidism were detected in Taltal or Chanaral; seven cases were detected in Antofagasta. Neonatal thyroid-stimulating hormone levels were significantly lower in Taltal compared with Antofagasta; this is opposite to the known pharmacological effect of perchlorate, and the magnitude of difference did not seem to be clinically significant. These findings do not support the hypothesis that perchlorate in drinking water at concentrations as high as 100 to 120 mu g/L suppresses thyroid function in newborns or school-age children.
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    Thyroid function in a population with an extra iodine intake
    (1998) Michaud, P; Tellez, R
    Background: After 20 years of iodine salt fortification, the prevalence of goiter has decreased significantly in the rural area of Pirque, central Chile. In this location, equipment has been installed that efficiently and economically adds 0.5 mg of elemental iodine per liter of water to render it potable. Aim: To study thyroid function and urinary iodine excretion in school age children of this zone, after two years of extra iodine intake. Material and methods: One hundred thirty four children aged 6 to 12 years old were examined. In 56 randomly chosen children a morning urine sample was obtained to measure iodine excretion. In 45 children without goiter, a blood sample was drawn to measure TSH and thyroxin. Results: In nine children (7%) a diffuse goiter was found. Median urinary iodine excretion was 158 mu g/dl. Thyroxin and TSH levels were within normal limits (8.4 +/- 1.1 mu g/dl and 2.2 +/- 1.5 mu U/ml respectively). During the period of iodine water supplementation there were 47 births in the zone. All newborns had normal TSH values and none had goiter. Conclusions: When present results are compared with the period before water iodination (when the prevalence of goiter was 9.6% and mean urinary iodine excretion was 57.6 mu g/dl), it can be concluded that extra iodine intake in this rural population has not caused additional thyroid problems.