Browsing by Author "Tapia Rojas, Cheril Cecilia"
Now showing 1 - 12 of 12
Results Per Page
Sort Options
- ItemAge Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease(2015) Inestrosa Cantín, Nibaldo; Rios, Juvenal A.; Cisternas, Pedro; Tapia Rojas, Cheril Cecilia; Rivera, Daniela S.; Braidy, Nady; Zolezzi, Juan M.; Godoy, Juan A.; Carvajal Cachaña, Francisco Javier; Ardiles, Alvaro O.
- ItemAlzheimer's Disease-Related Protein Expression in the Retina of Octodon degus(2015) Du, Lucia Y.; Chang, Lily Y-L.; Ardiles, Alvaro O.; Tapia Rojas, Cheril Cecilia; Araya, Joaquin; Inestrosa Cantín, Nibaldo; Palacios, Adrian G.; Acosta, Monica L.
- ItemAndrographolide Stimulates Neurogenesis in the Adult Hippocampus(2015) Varela, L.; Tapia Rojas, Cheril Cecilia; Inestrosa Cantín, Nibaldo
- ItemBeta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats(2015) Cuevas, Catherina A.; Tapia Rojas, Cheril Cecilia; Cespedes, Carlos; Inestrosa Cantín, Nibaldo; Vio Lagos, Carlos P.
- ItemInhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A beta)(42) peptides(2016) Tapia Rojas, Cheril Cecilia; Burgos, P.; Inestrosa Cantín, Nibaldo
- ItemIs L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice(2015) Tapia Rojas, Cheril Cecilia; Lindsay, Carolina B.; Montecinos Oliva, Carla; Arrazola Tello, Macarena Soledad.; Retamales, Rocio M.; Inestrosa Cantín, Nibaldo; Bunout, Daniel; Hirsch, Sandra.Abstract Background L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. Previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory and propose a role in brain function. However, some evidence indicates that an excess of methionine can be harmful and can increase the risk of developing Type-2 diabetes, heart diseases, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. Results Here, we report the effects of an L-methionine-enriched diet in wild-type mice and emphasize changes in brain structure and function. The animals in our studypresented 1) higher levels of phosphorylated tau protein, 2) increased levels of amyloid-β (Aβ)-peptides, including the formation of Aβ oligomers, 3) increased levels of inflammatory response,4) increased oxidative stress, 5) decreased level of synaptic proteins, and 6) memory impairment and loss. We also observed dysfunction of the Wnt signaling pathway. Conclusion Taken together, the results of our study indicate that an L-methionine-enriched diet causes neurotoxic effects in vivo and might contribute to the appearance of Alzheimer’s-like neurodegeneration.
- ItemLoss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease(2018) Tapia Rojas, Cheril Cecilia; Inestrosa Cantín, Nibaldo
- ItemPostsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease(2012) Ardiles, Alvaro O.; Tapia Rojas, Cheril Cecilia; Inestrosa Cantín, Nibaldo
- ItemRhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A beta PPswe/PS-1 Mice of Different Ages(2016) Serrano, Felipe G.; Tapia Rojas, Cheril Cecilia; Carvajal Cachaña, Francisco Javier; Cisternas, Pedro; Viayna, Elisabet; Sola, Irene; Muñoz Torrero, Diego; Inestrosa Cantín, Nibaldo
- ItemSynthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents(2014) Viayna, E.; Tapia Rojas, Cheril Cecilia; Serrano González, Felipe Andrés.; Inestrosa Cantín, Nibaldo
- ItemTetrahydrohyperforin inhibits the proteolytic processing of amyloid precursor protein and enhances its degradation by Atg5-dependent autophagy(2015) Cavieres, Viviana A.; González, Alexis; Muñoz, Vanessa C.; Yefi Rubio, Claudia Pamela; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia Rojas, Cheril Cecilia; Otth, Carola; Barrera, María José; Inestrosa Cantín, Nibaldo; Mardones, Gonzalo A.; González, Carlos; Burgos, Patricia V.
- ItemWnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling(2018) Ramos Fernández, E.; Tapia Rojas, Cheril Cecilia; Ramírez Fernández, Valerie Trinidad; Inestrosa Cantín, Nibaldo