Browsing by Author "Tapia, Jose L."

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    Breast milk production and emotional state in mothers of very low birth weight infants
    (2021) Wormald, Francisca; Tapia, Jose L.; Dominguez, Angelica; Canepa, Paula; Miranda, Angela; Torres, Gabriela; Rodriguez, Diana; Acha, Leila; Fonseca, Rosanna; Ovalle, Natalia; Anchorena, M. Luisa; Danner, Max
    Introduction. There is little evidence regarding the influence of emotional variables on breastfeeding among mothers of very low birth weight infants (VLBWIs). The objective of this study was to measure breast milk production (BMP) at two points in time during neonatal hospitalization and its association with anxiety, depression, and breastfeeding self-efficacy levels among mothers of VLBWIs.
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    Enteral Feeding and Necrotizing Enterocolitis: Does Time of First Feeds and Rate of Advancement Matter?
    (LIPPINCOTT WILLIAMS & WILKINS, 2021) Masoli, Daniela; Domínguez De Landa, María Angélica; Tapia, Jose L.; Uauy, Ricardo; Fabres, Jorge; NEOCOSUR Collaborative Network
    The aim of the study was to determine if time to initial enteral feeding (EF) and rate of advancement are associated with necrotizing enterocolitis (NEC) or death. Methods: Secondary analysis of prospectively collected data of very-low-birth-weight infants (VLBWI: 400--1500 g) born in 26 NEOCOSUR centers between 2000 and 2014. Results: Among 12,387 VLBWI, 83.7% survived without NEC, 6.6% developed NEC and survived, and 9.6% had NEC and died or died without NEC (NEC/death). After risk adjustment, time to initial EF (median = 2 days) was not associated with NEC; however, delaying it was protective for NEC/death (odds ratio [OR] = 0.96; 95% confidence interval [CI] 0.93--0.99). A slower feeding advancement rate (FAR) was protective for NEC (OR = 0.97; 95% CI = 0.94-0.98) and for NEC/death (OR = 0.98; 95% CI = 0.96-0.99). Conclusions: In VLBWI, there was no association between an early initial EF and NEC, although delaying it was associated with less NEC/death. A slower FAR was associated with lower risk of both outcomes.
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    Growth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial
    (2022) Masoli, Daniela; Mena, Patricia; Domínguez, Angélica; Ramolfo, Pamela; Vernal, Patricia; Pantoja, Miguel Angel; Esparza, Ruth; Hübner, Maria Eugenia; Ríos, Antonio; Faunes, Miriam; Uauy, Ricardo; Tapia, Jose L.; Neocosur Network
    Objectives: To evaluate growth (weight, length, head circumference, and knee–heel length [KHL]) in very low birth weight (VLBW) infants (500–1500 g) who received human milk with a liquid fortifier (LHMF) with high protein and fatty acid content versus a traditional powder fortifier (PHMF) for 45 days or until discharge. Methods: This was a multicenter, randomized, controlled trial. An intention-to-treat analysis was performed to determine adverse events and withdrawal causes. We also performed an efficacy analysis involving the infants who completed at least 2 weeks of study. Results: Of the 158 infants enrolled in the study, 146 completed at least 2 weeks, and 125 completed the entire study. The biodemographic characteristics were similar between groups, with no differences in increments of weight (22.9 vs 22.7 g kg−1 day−1), length (1.03 vs 1.09 cm/week), head circumference (0.91 vs 0.90 cm/week), or KHL (3.6 vs 3.3 mm/week). The KHL increment was greater in infants weighing >1 kg receiving LHMF (3.7 vs 3.2 mm/week, P = 0.027). Although there were no significant differences in serious adverse events, the incidence difference of the composite outcome death/necrotizing enterocolitis between groups warrants attention (1.3% with LHMF and 8.1% with PHMF). Conclusion: There were no differences in the overall growth between VLBW infants receiving either fortifier.
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    Mode of delivery and antenatal steroids and their association with survival and severe intraventricular hemorrhage in very low birth weight infants
    (2016) Hubner, M. E.; Ramirez, R.; Burgos, J.; Dominguez, A.; Tapia, J. L.; Colantonio, Guillermo; Zapata, Jorge; Perez, Gaston; Ana Pedraza, Susana Garcia; Kurlat, Isabel; Di Siervi, Oscar; Escarate, Adriana; Mariani, Gonzalo; Maria Ceriani, Jose; Fernandez, Silvia; Fustinana, Carlos; Brener, Pablo; Edwards, Eleonora; Tavosnaska, Jorge; Roldan, Liliana; Sexer, Hector; Saa, Gladys; Sabatelli, Debora; Laura Gendra, Maria; Fernanda Buraschi, Maria; Molina, Paula; Daniel, Agost; Morganti, Federico; Fontana, Adriana; Chandias, Daniela; Rinaldi, Monica; Grandi, Carlos; Rojas, Elio; Solana, Claudio; Nieto, Ricardo; Meritano, Javier; Larguia, Miguel; Kasten, Laura; Cuneo, Lucrecia; Decaro, Marcelo; Cracco, Lionel; Bassi, Gustavo; Jacobi, Noemi; Brum, Andrea; Vain, Nestor; Aguilar, Adriana; Guerrero, Miriam; Szyld, Edgardo; Escandar, Alcira; Abdala, Daniel; Guida, Martin; Ferrin, Lucila; Roge, Horacio; Musante, Gabriel; Capelli, Maria C.; Pablo Berazategui, Juan; de Elizalde, Magdalena; Ignacio Fraga, Juan; Keller, Rodolfo; Ahumada, Luis; Ferreyra, Mirta; Ferreira, Vanda; Borges, Roberta; Do Vale, Marynea; Cavalcante, Silvia; Gusmao, Joama; Franco, Patricia; Jose Silva, Maria; Fabres, Jorge; Estay, Alberto; Gonzalez, Alvaro; Kattan, Javier; Quezada, Mariela; Urzua, Soledad; Campos, Lilia; Cifuentes, Lilian; Leon, Jorge; Aguilar, Roxana; Treuer, Sergio; Giaconi, Jimena; Bancalari, Aldo; Standen, Jane; Escobar, Marisol; Veas, Viviana; Sandino, Daniela; Gonzalez, Agustina; Avila, Claudia; Guzman, Carla; Toro, Claudia; Mena, Patricia; Milet, Beatriz; Pittaluga, Enrica; Pena, Veronica; Mendizabal, Rafael; Pizarro, Dagoberto; D'Apremont, Ivonne; Tapia, Jose L.; Marshall, Guillermo; Villarroel, Luis; Quezada, Mariela; Dominguez, Angelica; Lacarruba, Jose; Cespedes, Elizabeth; Mir, Ramon; Mendieta, Elvira; Genes, Larissa; Caballero, Carlos; Webb, Veronica; Rivera, Fabiola; Llontop, Margarita; Bellomo, Sicilia; Zegarra, Jaime; Chumbes, Oscar; Castaneda, Anne; Cabrera, Walter; Llanos, Raul; Mucha, Jorge; Garcia, Gustavo; Ceruti, Beatriz; Borbonet, Daniel; Gugliucci, Sandra; Lain, Ana; Martinez, Mariza; Bazan, Gabriela; Piffaretti, Susana; Cuna, Isabel; Bermudez, Patricia
    OBJECTIVE: To determine whether CS delivery and receipt of antenatal steroids (ANS) in vertex-presenting singletons with a gestational age (GA) between 24 and 30 weeks is associated with improved survival and improved severe intraventricular hemorrhage (sIVH)-free survival.
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    Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants
    (2022) Chawla, Sanjay; Natarajan, Girija; Laptook, Abbot R.; Chowdhury, Dhuly; Bell, Edward F.; Ambalavanan, Namasivayam; Carlo, Waldemar A.; Gantz, Marie; Das, Abhik; Tapia, Jose L.; Harmon, Heidi M.; Shankaran, Seetha
    Background To develop a model for prediction of severe intracranial hemorrhage (ICH) or death based on variables from the first 12 h of age and to compare mortality and morbidities with and without exposure to early indomethacin. Methods This retrospective cohort study included extreme preterm (22(0/7)-26(6/7) weeks) infants born at National Institute of Child Health and Human Development Neonatal Research Network sites. Primary outcome was a composite of severe ICH and/or death. Results Of 4624 infants, 1827 received early indomethacin. Lower gestation, lack of antenatal steroids exposure, lower 1-min Apgar, male sex, and receipt of epinephrine were associated with severe ICH or death. Early indomethacin was associated with a lower risk of patent ductus arteriosus, bronchopulmonary dysplasia, and higher risk of spontaneous intestinal perforation. Conclusions A model for early prediction of severe ICH/death was developed and validated. Early indomethacin was associated with a lower risk of patent ductus arteriosus and bronchopulmonary dysplasia and a higher risk of spontaneous intestinal perforation. Impact Modern data on severe ICH and neonatal morbidities in relation to prophylactic indomethacin are scarce in the published literature. Prophylactic indomethacin was associated with a lower risk of patent ductus arteriosus and bronchopulmonary dysplasia and a higher risk of intestinal perforation. A risk estimator for severe intracranial hemorrhage/death was developed in a large cohort of extremely preterm infants. The risk estimator developed based on a large cohort of patients provides an estimate of severe intracranial bleeding for an individual infant.
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    Randomized Trial of Early Bubble Continuous Positive Airway Pressure for Very Low Birth Weight Infants
    (MOSBY-ELSEVIER, 2012) Tapia, Jose L.; Urzua, Soledad; Bancalari, Aldo; Meritano, Javier; Torres, Gabriela; Fabres, Jorge; Toro, Claudia A.; Rivera, Fabiola; Cespedes, Elizabeth; Burgos, Jaime F.; Mariani, Gonzalo; Roldan, Liliana; Silvera, Fernando; Gonzalez, Agustina; Dominguez, Angelica; S Amer Neocosur Network
    Objective To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation to CPAP; CPAP/INSURE) protocol, need less mechanical ventilation than those supported with supplemental oxygen, surfactant, and mechanical ventilation if required (Oxygen/mechanical ventilation [MV]).
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    Single vs. double phototherapy in the treatment of full-term newborns with nonhemolytic hyperbilirubinemia
    (SOC BRASIL PEDIATRIA, 2009) Silva, Ignacia; Luco, Matias; Tapia, Jose L.; Eugenia Perez, Maria; Antonio Salinas, Jose; Flores, Javiera; Villaroel, Luis
    Objectives: To compare the effectiveness of single (1 panel) vs. double (2 panels) phototherapy in reducing nonhemolytic hyperbilirubinemia in term newborns.
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    Stroke Patterns in Neonatal Group B Streptococcal Meningitis
    (ELSEVIER SCIENCE INC, 2011) Hernandez, Marta I.; Sandoval, Carmen C.; Tapia, Jose L.; Mesa, Tomas; Escobar, Raul; Huete, Isidro; Wei, Xing Chang; Kirton, Adam
    Neonatal group B streptococcus meningitis causes neurologic morbidity and mortality. Cerebrovascular involvement is a common, poorly studied, and potentially modifiable pathologic process. We hypothesized that imaging patterns of focal brain infarction are recognizable in neonatal group B streptococcal meningitis. A consecutive case series included term neonates with the following: (1) bacterial meningitis, (2) acute group B streptococcal infection (positive cerebrospinal fluid/blood culture), (3) brain magnetic resonance imaging within 14 days, and (4) acute intraparenchymal focal infarctions (restricted diffusion). Lesions within known arterial territories were classified as arterial ischemic stroke. Clinical presentations, investigations, and neurologic outcomes were recorded. Eight newborns (50% female) with focal infarction were identified. Five presented early (<1 week), and all manifested clinical shock and elevated acute-phase reactants. Less than 50% had prenatal group B streptococcal screening, while 2 of 3 screened were negative. Two distinct patterns of focal infarction were identified: (1) deep perforator arterial stroke to basal ganglia, thalamus, and peri ventricular white matter (7/8, 88%), and (2) superficial injury with patchy, focal infarctions of the cortical surface (6/8, 75%). Outcomes (mean 23.8 months) were poor, with severe disability or death in 6/8 (75%). Recognizable stroke patterns contribute to severe neurologic outcomes and represent a potentially modifiable pathophysiologic process in neonatal group B streptococcal meningitis. (C) 2011 Elsevier Inc. All rights reserved.
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    Survival and Survival without Major Morbidity Seem to Be Consistently Better throughout Gestational Age in 24-to 30-Week Gestational Age Very-Low-Birth-Weight Female Infants Compared to Males
    (2022) Garcia-Munoz Rodrigo, Fermin; Fabres, Jorge G.; Zozaya Nieto, Carlos; San Feliciano, Laura; Figueras-Aloy, Josep; Saenz de Pipaon, Miguel; D'Apremont, Ivonne; Genes de Lovera, Larissa E.; Bancalari, Aldo; Tapia, Jose L.; Vento, Maximo
    Introduction: Several studies showed advantages in outcomes for very-low-birth-weight (VLBW) female infants. It has been suggested that recent advances in perinatal care might have benefited boys relatively more than girls, making differences disappear. Objectives: The aims of the study were (1) to determine if sex differences in survival and survival without morbidity in VLBW infants are still present in the context of more advanced perinatal care and (2) to know whether these differences are consistent throughout gestational age (GA). Methods: Retrospective cohort study in seven countries participating in the Spanish SEN1500 and the South American NEOCOSUR neonatal networks. We included VLBW infants 24-30 weeks' GA, born alive without major congenital anomalies (2013-2016). Major morbidity, survival, and survival without morbidity were compared between male and female infants overall and stratified by GA. Results: 10,565 patients were included: 5,620 (53.2%) males and 4,945 (46.8%) females. Female infants exhibited a lower incidence rate ratio (95% CI) of respiratory distress syndrome: 0.91 (0.88, 0.94), necrotizing enterocolitis: 0.83 (0.74, 0.93), major brain damage: 0.79 (0.72, 0.86), moderate-severe bronchopulmonary dysplasia (BPD): 0.77 (0.72, 0.83), higher survival: 1.03 (1.01, 1.05), survival without BPD: 1.11 (1.07, 1.16), survival without major brain damage: 1.05 (1.02, 1.08), and survival without major morbidity: 1.14 (1.07, 1.21). Survival and survival without morbidity were almost consistently favourable to females throughout GA. Conclusions: Our findings suggest that perinatal results continue to be favourable for VLBW female infants in the context of current perinatology, and that they are almost consistent throughout GA.
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    Syndrome of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) in siblings
    (2009) Valenzuela, Patricia M.; Majerson, Daniela; Tapia, Jose L.; Talesnik, Eduardo
    PFAPA syndrome is characterized by episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. PFAPA syndrome usually begins in children under 5 years old and normally has self-resolution. The etiology of PFAPA syndrome remains unknown. In this paper, we report the cases of two different families with siblings with PFAPA syndrome: two sisters and two brothers. To our knowledge, this is the first report of siblings with PFAPA syndrome.