Browsing by Author "Talesnik Guendelman, Eduardo"

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    Características clínicas asociadas a colitis eosinofílica en lactantes con rectorragia persistente
    (2014) Romero, Bernardita; Talesnik Guendelman, Eduardo; Cerda, Jaime; Harris D., Paul R.
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    Características clínicas e inmunológicas de veinte pacientes con síndrome de DiGeorge
    (2005) Passero, L. M.; Contreras, P.; González Pérez, P; Carrión, F.; Navarrete, C; Méndez, C; Quezada, A; King, A; Talesnik Guendelman, Eduardo
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    Chronic nonbacterial osteomyelitis in children: a multicenter case series
    (2020) Concha, S; Hernández-Ojeda, A; Contreras Olea, Oscar; Mendez, C; Talesnik Guendelman, Eduardo; Borzutzky Schachter, Arturo
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    Clinical characterization of Chilean patients with ige-mediated food allergy
    (2018) Feuerhake, Teo; Aguilera Insunza, Raquel; Morales Matamala, Pamela Soledad; Talesnik Guendelman, Eduardo; Linn, Katherina; Thöne, Natalie Andrea; Borzutzky Schachter, Arturo
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    Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity
    (2014) Borzutzky Schachter, Arturo; Seiltgens, Cristián; Iruretagoyena B., Mirentxu; Cristi, Francisca; Ponce, María Jesús ; Melendez, Patricia; Martínez Aguayo, Alejandro; Hodgson Bunster, María Isabel; Talesnik Guendelman, Eduardo; Riera Cassorla, Francisca Paz; Méndez, Cecilia; Harris D., Paul R.; García Bruce, Hernán; Gana Ansaldo, Juan Cristóbal; Godoy, Claudia; Cattani Ortega, Andreína
    Background/Purpose:Autoimmune diseases (AIDs) have familial aggregation and frequently share a common genetic background, but few studies have evaluated autoimmune clusters in children with AIDs and their families. Children with more than one AID (pediatric polyautoimmunity) may have a stronger genetic component than children with a single AID. The objectives of this study were to identify clusters of AIDs in children and their first-degree relatives and to evaluate the association of PTPN22 C1858T gene polymorphism with pediatric polyautoimmunity.Methods:A cross-sectional study was performed in subjects with an AID of pediatric onset (<18 years)recruited at Pediatric Rheumatology, Endocrinology and Gastroenterology Clinics at the Health Network of the Pontificia Universidad Católica de Chile School of Medicine. Clusters of AIDs were identified by K-means cluster analysis. The PTPN22 C1858T gene polymorphism was determined by RT-PCR in subjects with pediatric polyautoimmunity and in subjects with three common AIDs: juvenile idiopathic arthritis (JIA), autoimmune thyroid disease (AITD), and type I diabetes (T1D).Results:191 subjects with pediatric AIDs were included, of which 45 (24%) had polyautoimmunity. Mean age was 12.1 years (range 1–19) and 68% were female. Most frequent AIDs were JIA (36%), AITD (25%), T1D (19%), uveitis (8%), celiac disease (6%), and vitiligo (6%). 59% of subjects with pediatric autoimmunity had first-degree relatives with an AID. Five clusters of AID were identified in families of children with autoimmunity (Table 1). Among the 45 subjects with pediatric polyautoimmunity, four clusters of AIDs were identified (Table 2). Genomic DNA from 128 subjects was evaluated for PTPN22 C1858T gene polymorphism revealing common homozygosity (C/C) in 85.2%, heterozygosity (C/T) in 13.3%, and rare homozygosity (T/T) in 1.6 %, in equilibrium with Hardy Weinberg equation (P = 0.4). 26% of polyautoimmune subjects had the T allele in contrast with 11% of monoautoimmune subjects (P = 0.04). No significant difference was found in the age of onset of autoimmunity between mono and polyautoimmune subjects (P = 0.44) or between subjects with C/C genotype vs. C/T and T/T genotypes (P = 0.81).
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    Clusters of Autoinmune Diseases in Children
    (KARGER, 2016) Seiltgens, Sorrel Cristian; Iruretagoyena Bruce, Mirentxu Ines; Melendez Escobar, Patricia Eugenia; Ponce Arqueros, Maria Jesus; Talesnik Guendelman, Eduardo; Méndez Rivera, Cecilia Del Pilar; Godoy Cortes, Claudia Loreto; Martinez Aguayo, Alejandro Gregorio; Hogdson, Isabel; Harris Diez, Paul Richard; Gana, Juan Cristobal; Riera Cassorla, Francisca Paz; Garcia Bruce, Hernán Gabriel; Cattani Ortega, Andreina; Borzutzky Schachter, Arturo Jose
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    Distribución geográfica de la enfermedad de Kawasaki en Chile
    (2016) Hoyos Bachiloglu, Rodrigo Andrés; García, A.; Morales Matamala, Pamela Soledad; Cerda, Jaime; Talesnik Guendelman, Eduardo; Borzutzky Schachter, Arturo
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    First report of the hyper-IgM syndrome registry of the latin american society for immunodeficiencies : Novel mutations, unique infections, and outcomes
    (2014) Cabral-Marques, O; Klaver, S.; Schimke, L.; Ascendino, E.; Khan, T.; Pereira, P.; Falcai, A.; Vargas, A.; Santos, L.; Talesnik Guendelman, Eduardo
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    Food allergy markers in peptic disease
    (2009) Talesnik Guendelman, Eduardo; Majerson Grinberg, Daniela; Serrano Honeyman, Carolina Andrea; Einisman Fleiderman, Helly Jael; Aravena González, Carmen Fabiola; Peña Villegas, Alfredo Javier; Ros Torres, Javiera Ignacia; Duarte Garcia, De Cortázar Ignacio; Harris Diez, Paul Richard
    Background: The double-blind food challenge is the gold standard for diagnosis of food allergy, eventhough it is difficult to standardize and execute. An increase in allergy prevalence worldwide accentuates the importance of evaluating food allergy markers, in order to help the diagnosis. Objective: Elaboration of an operational definition for food hypersensitivity (FH) and evaluate the role of allergy markers, endoscopic and hystological findings, gastric mucosa cytokines and personal/family history of allergy in children. Method: Enrollment of children with suspected peptic disease referred for endoscopy. We obtained antral biopsies for hystological evaluation (eosinophil and mast cell count) and measurement of mucosal cytokines through an ELISA test. Patients were evaluated with Prick test, total serum IgE and clinical questionnaires for allergies. They were divided into two groups; children with and without food hypersensitivity. Results: 97 children were enrolled (mean: 11.7 ± 3, range 3-18). 4% of children had FH. The endoscopic findings did not correlate with the presence of FH. 74.1% of patients without FH had eosinophils in the gastric mucosa compared to groups with FH which had 100% (p < 0.05). Only IL-2 among the evaluated cytokines was found in a greater concentration in patients without FH. 33% of patients considered themselves having history of personal allergies versus 11.8% of people without FH (p < 0.05). Conclusions: 12,4% of children with digestive symptoms referred to endoscopy have FH. There are no clinical, endoscopic or hystological differences between patients with or without FH.
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    Higher latitude and lower solar radiation influence on anaphylaxis in Chilean children
    (2014) Hoyos Bachiloglu, Rodrigo Andrés; Morales Matamala, Pamela Soledad; Cerda, Jaime; Talesnik Guendelman, Eduardo; González Vicente, Gilberto; Camargo, C.; Borzutzky Schachter, Arturo
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    Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome
    (2013) Valenzuela Contreras, Patricia; Araya del Pino, Andrea Paz; Pérez, Carlos; Maul Fonseca, Ximena; Serrano Honeyman, Carolina; Harris D., Paul R.; Talesnik Guendelman, Eduardo; Valenzuela Contreras, Patricia; Araya del Pino, Andrea Paz; Pérez, Carlos; Maul Fonseca, Ximena; Serrano Honeyman, Carolina; Harris D., Paul R.; Talesnik Guendelman, Eduardo
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    Pruebas cutáneas de hipersensibilidad inmediata en una población pediátrica seleccionada
    (SOC MEDICA SANTIAGO, 2005) Martínez Gutiérrez, Javiera; Méndez Rivera, Cecilia del Pilar; Talesnik Guendelman, Eduardo; Campos R., Eugenia; Viviani García, Paola; Sánchez Díaz, Ignacio
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    Rising hospitalization rates of Kawasaki disease in Chile between 2001 and 2007
    (2011) Borzutzky Schachter, Arturo; Hoyos Bachiloglu, Rodrigo Andrés; Cerda Lorca, Jaime Rodrigo; Talesnik Guendelman, Eduardo