Browsing by Author "Steinmaus, Craig"

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    Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000
    (2007) Yuan, Yan; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Steinmaus, Craig; Selvin, Steve; Liaw, Jane; Bates, Michael N.; Smith, Allan H.
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    Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation
    (OXFORD UNIV PRESS INC, 2018) Roh, Taehyun; Steinmaus, Craig; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Liaw, Jane; Smith, Allan H.
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    Arsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile
    (Springer Science and Business Media B.V., 2025) Blanco, Estela; Acevedo, Johanna; Perez, Liliana; Herrera, Marian; Duran, Viviana; Barlaro, Teresa; Meza, Rodrigo; Roa, Juan Carlos; Parra, Roxana; Benitez, Hugo; Schwalb, Molly E.; Steinmaus, Craig; Ferreccio, Catterina
    Purpose Exposure to arsenic in drinking water is a cause of lung, bladder, and skin cancer, however the relation between arsenic and breast cancer is unclear. Northern Chile had high levels of arsenic in drinking water (up to 900 mu g/l) between 1950 and 1970, facilitating the study of outcomes with long latency. We conducted a breast cancer case-control study in Northern Chile (2014-2018) and analyzed 505 incident breast cancer cases and 409 population-based female controls with data collected on lifetime exposure to arsenic and potential confounders. Methods We identified cases in collaboration with cancer committees, hospitals, and medical facilities in the study area. Controls were recruited from the Chile Voter Registry. Logistic regression was used to assess the relationship between arsenic exposure and breast cancer adjusting for education and age. We evaluated cumulative, lifetime average and highest single year exposure with tertiles and quartiles and population weighted controls based on age and region of residence. Results Exposure levels were high in both cases and controls, with median (interquartile range) values of: 52 (15-84) and 42 (10-106) mu g/L for average lifetime concentration, respectively. Adjusted odds ratios (OR) for tertile of cumulative exposure to arsenic concentrations in water (< 1.17, 1.17-5.16, and >= 5.17 mg) were 1.00, 0.85 [95% confidence interval (CI), 0.60-1.18], and 1.10 (0.79-1.55). Results were similar for lifetime average and single-highest year exposure metrics. Conclusion We did not find evidence of increased odds of higher arsenic exposure among incident breast cancer cases compared to female population controls.
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    Arsenic in drinking water and prostate cancer: A population-based case-control study in Northern Chile
    (2025) Schwalb, Molly E.; Ferreccio Readi, Catterina; Blanco, Estela; Smith, Allan H.; Steinmaus, Craig
    Background: Epidemiologic evidence demonstrates increased lung, bladder, and skin cancer riskamong individuals exposed to arsenic in drinking water. Some studies report associations withprostate cancer, but data are limited. This study aimed to examine the association between arsenicin drinking water and prostate cancer in Northern Chile. With its wide range of exposure (<10–860μg/L), large population, and accurate information on historical exposures, Northern Chile is thebest place to investigate the human carcinogenic effects of arsenic.Methods: A case-control study conducted from 2015–2019 enrolled 343 prostate cancer casesand 337 age-matched controls among men aged ≥40 years. Cases were ascertained from cancercommittees, hospitals, and medical facilities in the area. Controls were ascertained from the ChileVoter Registry, including >90% of adults aged >50 years. Information on lifetime arsenic exposureand potential confounders such as smoking, family history, and prostate cancer screening werecollected.Results: Twenty-three percent of participants were exposed to arsenic concentrations >800 μg/Lin their lifetime (80x recommended thresholds). Cases and controls were demographically similar.After adjustment for age and smoking status, participants with the highest quartile of lifetimecumulative and average arsenic concentrations in drinking water each had 1.14 (95%CI 0.71–1.84)and 1.17 (95%CI 0.73–1.89) times the odds of prostate cancer compared to participants with thelowest quartile of exposure, respectively.Conclusions: Arsenic exposure in drinking water, even at high levels, was not associated withincreased risk of prostate cancer.
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    Arsenic, Tobacco Smoke, and Occupation Associations of Multiple Agents with Lung and Bladder Cancer
    (2013) Ferreccio Readi, Catterina; Yuan, Yan; Calle, Jacqueline; Benítez, Hugo; Parra, Roxana L.; Acevedo, Johanna; Smith, Allan H.; Liaw, Jane; Steinmaus, Craig
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    Case-Control Study of Arsenic in Drinking Water and Kidney Cancer in Uniquely Exposed Northern Chile
    (2013) Ferreccio Readi, Catterina; Smith, Allan H.; Durán, Viviana; Barlaro, Teresa; Benítez, Hugo; Valdés, Rodrigo O.; Aguirre, Juan José; Moore, Lee E.; Acevedo, Johanna; Vásquez, María Isabel; Pérez, Liliana; Yuan, Yan; Liaw, Jane; Cantor, Kenneth P.; Steinmaus, Craig
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    Elevated Lung Cancer in Younger Adults and Low Concentrations of Arsenic in Water
    (2014) Steinmaus, Craig; Ferreccio Readi, Catterina; Yuan, Yan; Acevedo, Johanna; González, Francisca; Pérez, Liliana; Cortés Arancibia, Sandra; Balmes, John R.; Liaw, Jane; Smith, Allan H.
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    Evidence From Chile That Arsenic in Drinking Water May Increase Mortality From Pulmonary Tuberculosis
    (2011) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yan; Liaw, Jane; Ferreccio Readi, Catterina; Steinmaus, Craig
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    Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes
    (2021) Bozack, Anne K.; Boileau, Philippe; Wei, Linqing; Hubbard, Alan E.; Sillé, Fenna C. M.; Ferreccio Readi, Catterina; Acevedo Romo, Johanna Patricia; Hou, Lifang; Ilievski, Vesna; Steinmaus, Craig; Bozack, Anne K.; Boileau, Philippe; Wei, Linqing; Hubbard, Alan E.; Sillé, Fenna C. M.; Ferreccio Readi, Catterina; Acevedo Romo, Johanna Patricia; Hou, Lifang; Ilievski, Vesna; Steinmaus, Craig
    Abstract Background Arsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populations and comparison across EWAS has been limited by methodological differences. Leveraging data from epidemiological studies conducted in Chile and Bangladesh, we use a harmonized data processing and analysis pipeline and meta-analysis to combine results from four EWAS. Methods DNAm was measured among adults in Chile with and without prenatal and early-life As exposure in PBMCs and buccal cells (N = 40, 850K array) and among men in Bangladesh with high and low As exposure in PBMCs (N = 32, 850K array; N = 48, 450K array). Linear models were used to identify differentially methylated positions (DMPs) and differentially variable positions (DVPs) adjusting for age, smoking, cell type, and sex in the Chile cohort. Probes common across EWAS were meta-analyzed using METAL, and differentially methylated and variable regions (DMRs and DVRs, respectively) were identified using comb-p. KEGG pathway analysis was used to understand biological functions of DMPs and DVPs. Results In a meta-analysis restricted to PBMCs, we identified one DMP and 23 DVPs associated with arsenic exposure; including buccal cells, we identified 3 DMPs and 19 DVPs (FDR < 0.05). Using meta-analyzed results, we identified 11 DMRs and 11 DVRs in PBMC samples, and 16 DMRs and 19 DVRs in PBMC and buccal cell samples. One region annotated to LRRC27 was identified as a DMR and DVR. Arsenic-associated KEGG pathways included lysosome, autophagy, and mTOR signaling, AMPK signaling, and one carbon pool by folate. Conclusions Using a two-step process of (1) harmonized data processing and analysis and (2) meta-analysis, we leverage four DNAm datasets from two continents of individuals exposed to high levels of As prenatally and during adulthood to identify DMPs and DVPs associated with arsenic exposure. Our approach suggests that standardizing analytical pipelines can aid in identifying biological meaningful signals.
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    Fifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water
    (2007) Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Yuan, Yan; Bates, Michael N.; Steinmaus, Craig; Selvin, Steve; Liaw, Jane; Smith, Allan H.
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    Hypertension among adults exposed to drinking water arsenic in Northern Chile
    (2017) Cortés Arancibia, Sandra; Ferreccio Readi, Catterina; Hall, Emily; Smith, Allan; Steinmaus, Craig; Gonzalez, Francisca
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    Increased childhood liver cancer mortality and arsenic in drinking water in northern Chile
    (2008) Liaw, Jane; Marshall Rivera, Guillermo; Yuan, Yan; Ferreccio Readi, Catterina; Steinmaus, Craig; Smith, Allan H.
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    Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure
    (2014) Steinmaus, Craig; Ferreccio Readi, Catterina; Acevedo, J.; Villagra, V.; Steinmaus, C.; Yuan, Y.; Liaw, J.; Duran, V.; Cuevas, S.
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    Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood
    (US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2006) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yuan; Ferreccio Readi, Catterina; Liaw, Jane; von Ehrenstein, Ondine; Steinmaus, Craig; Bates, Michael N.; Selvin, Steve
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    Kidney Cancer Mortality Fifty-year Latency Patterns Related to Arsenic Exposure
    (LIPPINCOTT WILLIAMS & WILKINS, 2010) Yuan, Yan; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Steinmaus, Craig; Liaw, Jane; Bates, Michael; Smith, Allan H.
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    Lung, bladder, and kidney cancer mortality 40 years after arsenic exposure reduction
    (2018) Smith, Allan H.; Marshall Rivera, Guillermo; Roh, Taehyun; Ferreccio Readi, Catterina; Liaw, Jane; Steinmaus, Craig
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    Mortality in Young Adults following in Utero and Childhood Exposure to Arsenic in Drinking Water
    (US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2012) Smith, Allan H.; Marshall Rivera, Guillermo; Liaw, Jane; Yuan, Yan; Ferreccio Readi, Catterina; Steinmaus, Craig
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    Obesity and increased susceptibility to arsenic-related type 2 diabetes in northern Chile
    (2018) Castriota, Felicia; Acevedo, Johanna; Ferreccio Readi, Catterina; Smith, Allan H.; Liaw, Jane; Smith, Martyn T.; Steinmaus, Craig
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    Rapid Reduction in Breast Cancer Mortality With Inorganic Arsenic in Drinking Water
    (ELSEVIER SCIENCE BV, 2014) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yan; Steinmaus, Craig; Ferreccio Readi, Catterina; Liaw, Jane; Smith, Martyn T.; Wood, Lily; Heirich, Marissa; Fritzemeier, Rebecca M.; Pegram, Mark D.