Browsing by Author "Steinmaus, Craig"
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- ItemAcute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000(2007) Yuan, Yan; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Steinmaus, Craig; Selvin, Steve; Liaw, Jane; Bates, Michael N.; Smith, Allan H.
- ItemAge at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation(OXFORD UNIV PRESS INC, 2018) Roh, Taehyun; Steinmaus, Craig; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Liaw, Jane; Smith, Allan H.
- ItemArsenic, Tobacco Smoke, and Occupation Associations of Multiple Agents with Lung and Bladder Cancer(2013) Ferreccio Readi, Catterina; Yuan, Yan; Calle, Jacqueline; Benítez, Hugo; Parra, Roxana L.; Acevedo, Johanna; Smith, Allan H.; Liaw, Jane; Steinmaus, Craig
- ItemAssociations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population(2017) De la Rosa, Rosemarie; Steinmaus, Craig; Akers, Nicholas K.; Conde, Lucia; Ferreccio Readi, Catterina
- ItemCase-Control Study of Arsenic in Drinking Water and Kidney Cancer in Uniquely Exposed Northern Chile(2013) Ferreccio Readi, Catterina; Smith, Allan H.; Durán, Viviana; Barlaro, Teresa; Benítez, Hugo; Valdés, Rodrigo O.; Aguirre, Juan José; Moore, Lee E.; Acevedo, Johanna; Vásquez, María Isabel; Pérez, Liliana; Yuan, Yan; Liaw, Jane; Cantor, Kenneth P.; Steinmaus, Craig
- ItemElevated Lung Cancer in Younger Adults and Low Concentrations of Arsenic in Water(2014) Steinmaus, Craig; Ferreccio Readi, Catterina; Yuan, Yan; Acevedo, Johanna; González, Francisca; Pérez, Liliana; Cortés Arancibia, Sandra; Balmes, John R.; Liaw, Jane; Smith, Allan H.
- ItemEvidence From Chile That Arsenic in Drinking Water May Increase Mortality From Pulmonary Tuberculosis(2011) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yan; Liaw, Jane; Ferreccio Readi, Catterina; Steinmaus, Craig
- ItemExposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes(2021) Bozack, Anne K.; Boileau, Philippe; Wei, Linqing; Hubbard, Alan E.; Sillé, Fenna C. M.; Ferreccio Readi, Catterina; Acevedo Romo, Johanna Patricia; Hou, Lifang; Ilievski, Vesna; Steinmaus, Craig; Bozack, Anne K.; Boileau, Philippe; Wei, Linqing; Hubbard, Alan E.; Sillé, Fenna C. M.; Ferreccio Readi, Catterina; Acevedo Romo, Johanna Patricia; Hou, Lifang; Ilievski, Vesna; Steinmaus, CraigAbstract Background Arsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populations and comparison across EWAS has been limited by methodological differences. Leveraging data from epidemiological studies conducted in Chile and Bangladesh, we use a harmonized data processing and analysis pipeline and meta-analysis to combine results from four EWAS. Methods DNAm was measured among adults in Chile with and without prenatal and early-life As exposure in PBMCs and buccal cells (N = 40, 850K array) and among men in Bangladesh with high and low As exposure in PBMCs (N = 32, 850K array; N = 48, 450K array). Linear models were used to identify differentially methylated positions (DMPs) and differentially variable positions (DVPs) adjusting for age, smoking, cell type, and sex in the Chile cohort. Probes common across EWAS were meta-analyzed using METAL, and differentially methylated and variable regions (DMRs and DVRs, respectively) were identified using comb-p. KEGG pathway analysis was used to understand biological functions of DMPs and DVPs. Results In a meta-analysis restricted to PBMCs, we identified one DMP and 23 DVPs associated with arsenic exposure; including buccal cells, we identified 3 DMPs and 19 DVPs (FDR < 0.05). Using meta-analyzed results, we identified 11 DMRs and 11 DVRs in PBMC samples, and 16 DMRs and 19 DVRs in PBMC and buccal cell samples. One region annotated to LRRC27 was identified as a DMR and DVR. Arsenic-associated KEGG pathways included lysosome, autophagy, and mTOR signaling, AMPK signaling, and one carbon pool by folate. Conclusions Using a two-step process of (1) harmonized data processing and analysis and (2) meta-analysis, we leverage four DNAm datasets from two continents of individuals exposed to high levels of As prenatally and during adulthood to identify DMPs and DVPs associated with arsenic exposure. Our approach suggests that standardizing analytical pipelines can aid in identifying biological meaningful signals.
- ItemFifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water(2007) Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Yuan, Yan; Bates, Michael N.; Steinmaus, Craig; Selvin, Steve; Liaw, Jane; Smith, Allan H.
- ItemHypertension among adults exposed to drinking water arsenic in Northern Chile(2017) Cortés Arancibia, Sandra; Ferreccio Readi, Catterina; Hall, Emily; Smith, Allan; Steinmaus, Craig; Gonzalez, Francisca
- ItemIncreased childhood liver cancer mortality and arsenic in drinking water in northern Chile(2008) Liaw, Jane; Marshall Rivera, Guillermo; Yuan, Yan; Ferreccio Readi, Catterina; Steinmaus, Craig; Smith, Allan H.
- ItemIncreased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure(2014) Steinmaus, Craig; Ferreccio Readi, Catterina; Acevedo, J.; Villagra, V.; Steinmaus, C.; Yuan, Y.; Liaw, J.; Duran, V.; Cuevas, S.
- ItemIncreased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood(US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2006) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yuan; Ferreccio Readi, Catterina; Liaw, Jane; von Ehrenstein, Ondine; Steinmaus, Craig; Bates, Michael N.; Selvin, Steve
- ItemKidney Cancer Mortality Fifty-year Latency Patterns Related to Arsenic Exposure(LIPPINCOTT WILLIAMS & WILKINS, 2010) Yuan, Yan; Marshall Rivera, Guillermo; Ferreccio Readi, Catterina; Steinmaus, Craig; Liaw, Jane; Bates, Michael; Smith, Allan H.
- ItemLung, bladder, and kidney cancer mortality 40 years after arsenic exposure reduction(2018) Smith, Allan H.; Marshall Rivera, Guillermo; Roh, Taehyun; Ferreccio Readi, Catterina; Liaw, Jane; Steinmaus, Craig
- ItemMortality in Young Adults following in Utero and Childhood Exposure to Arsenic in Drinking Water(US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2012) Smith, Allan H.; Marshall Rivera, Guillermo; Liaw, Jane; Yuan, Yan; Ferreccio Readi, Catterina; Steinmaus, Craig
- ItemObesity and increased susceptibility to arsenic-related type 2 diabetes in northern Chile(2018) Castriota, Felicia; Acevedo, Johanna; Ferreccio Readi, Catterina; Smith, Allan H.; Liaw, Jane; Smith, Martyn T.; Steinmaus, Craig
- ItemRapid Reduction in Breast Cancer Mortality With Inorganic Arsenic in Drinking Water(ELSEVIER SCIENCE BV, 2014) Smith, Allan H.; Marshall Rivera, Guillermo; Yuan, Yan; Steinmaus, Craig; Ferreccio Readi, Catterina; Liaw, Jane; Smith, Martyn T.; Wood, Lily; Heirich, Marissa; Fritzemeier, Rebecca M.; Pegram, Mark D.
- ItemSocioeconomic status and the association between arsenic exposure and type 2 diabetes(2019) Eick, Stephanie M.; Ferreccio, Catterina; Acevedo, Johanna; Castriota, Felicia; Cordero, Jose F.; Roh, Taehyun; Smith, Allan H.; Smith, Martyn T.; Steinmaus, CraigObjective: Evaluate whether arsenic-related diabetes risks differ between people of low and high socioeconomic status (SES).
- ItemThe impact of BMI on non-malignant respiratory symptoms and lung function in arsenic exposed adults of Northern Chile(2017) Nardone, Anthony; Ferreccio Readi, Catterina; Acevedo, Johanna; Enanoria, Wayne; Blair, Alden; Smith, Allan H.; Balmes, John; Steinmaus, Craig