Browsing by Author "Soto Donoso, Katherine."

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    Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis
    (2017) Sarmiento Maldonado, Mauricio; Bertín Cortes Monroy, Pablo; Jara Arias, Verónica.; Soto Donoso, Katherine.; Uribe González, Pablo Francisco; Ocqueteau Tachini, Mauricio; Ramírez Villanueva, Pablo Antonio; Perez Simón, José Antonio.
    Abstract Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib. Three patients had acute GVHD (1 pulmonary, 2 cutaneous, 1 multi-systemic) and 5 had chronic GVHD (3 cutaneous); 85% obtained an overall response and 50% a complete response with a tolerable toxicity profile. Conclusions In our series, Ruxolitinib was very active as a rescue therapy for patients with acute or chronic GVHD refractory to standard treatment.