Browsing by Author "Sommer, Claudia"

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    Future perspectives: the next fifty years of the International Association for the Study of Pain
    (2023) Sommer, Claudia; Calvo Bascuñán, Margarita; Cervero, Fernando; Loeser, John D.
    The International Association for the Study of Pain (IASP) has become the leading professional association dedicated to promoting pain research and management. Through its many activities, including research funding, educational programs, advocacy initiatives, and global collaborations, the Association has significantly contributed to the understanding and treatment of pain. Looking into the future, the IASP is determined to continue its mission of reducing the burden of pain on individuals and societies worldwide. Here, we explore how current and past activities of the IASP will shape the future of pain research, treatment, education, and advocacy as well as provide a valuable service to its members across the world.
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    Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies
    (2025) Villa, Sara; Aasvang, Eske K.; Attal, Nadine; Baron, Ralf; Bourinet, Emmanuel; Calvo Bascuñán, Margarita; Finnerup, Nanna B.; Galosi, Eleonora; Hockley, James R. F.; Karlsson, Pall; Kemp, Harriet; Koerner, Jannis; Kutafina, Ekaterina; Lampert, Angelika; Murk, Margarita; Nochi, Zahra; Price, Theodore J.; Rice, Andrew S. C.; Sommer, Claudia; Taba, Pille
    Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.