Browsing by Author "Sobrevia Luarte, Luis Alberto"

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    Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis
    (2025) Etchegaray-Armijo, Karina; Bustos-Arriagada, Edson; Navarro-Rosenblatt, Deborah; Vera Peréz-Gacitua, Claudio Mauricio; Garmendia, María Luisa; Sobrevia Luarte, Luis Alberto; López Alarcon, Camilo Ignacio; Casanello Toledo, Paola Cecilia
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    Placental mitochondrial impairment and its association with maternal metabolic dysfunction
    (WILEY, 2024) Grismaldo, R. Adriana; Luevano-Martinez, Luis A.; Reyes, Monserrat; Garcia-Marquez, Grecia; Garcia-Rivas, Gerardo; Sobrevia Luarte, Luis Alberto
    The placenta plays an essential role in pregnancy, leading to proper fetal development and growth. As an organ with multiple physiological functions for both mother and fetus, it is a highly energetic and metabolically demanding tissue. Mitochondrial physiology plays a crucial role in the metabolism of this organ and thus any alteration leading to mitochondrial dysfunction has a severe outcome in the development of the fetus. Pregnancy-related pathological states with a mitochondrial dysfunction outcome include preeclampsia and gestational diabetes mellitus. In this review, we address the role of mitochondrial morphology, metabolism and physiology of the placenta during pregnancy, highlighting the roles of the cytotrophoblast and syncytiotrophoblast. We also describe the relationship between preeclampsia, gestational diabetes, gestational diabesity and pre-pregnancy maternal obesity with mitochondrial dysfunction. image, Abstract figure legend Diseases of pregnancy such as preeclampsia, gestational diabetes mellitus, pre-pregnancy maternal obesity and obesity in pregnancy result in dysfunctional mitochondria, leading to altered fetal development and growth with consequences for young and adulthood. Created with BioRender.com. image
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    The LINC complex in blood vessels: from physiology to pathological implications in arterioles
    (John Wiley and Sons Inc, 2025) Ferreira G.; Cardozo R.; Chavarria L.; Santander A.; Sobrevia Luarte, Luis Alberto; Chang W.; Gundersen G.; Nicolson G.L.
    © 2025 The Authors. The Journal of Physiology © 2025 The Physiological Society.The LINC (linker of nucleoskeleton and cytoskeleton) complex is a critical component of the cellular architecture that bridges the nucleoskeleton and cytoskeleton and mediates mechanotransduction to and from the nucleus. Though it plays important roles in all blood vessels, it is in arterioles that this complex plays a pivotal role in maintaining endothelial cell integrity, regulating vascular tone, forming new microvessels and modulating responses to mechanical and biochemical stimuli. It is also important in vascular smooth muscle cells and fibroblasts, where it possibly plays a role in the contractile to secretory phenotypic transformation during atherosclerosis and vascular ageing, and in fibroblasts' migration and inflammatory responses in the adventitia. Physiologically, the LINC complex contributes to the stability of arteriolar structure, adaptations to changes in blood flow and injury repair mechanisms. Pathologically, dysregulation or mutations in LINC complex components can lead to compromised endothelial function, vascular remodelling and exacerbation of cardiovascular diseases such as atherosclerosis (arteriolosclerosis). This review summarizes our current understanding of the roles of the LINC complex in cells from arterioles, highlighting its most important physiological functions, exploring its implications for vascular pathology and emphasizing some of its functional characteristics in endothelial cells. By elucidating the LINC complex's role in health and disease, we aim to provide insights that could improve future therapeutic strategies targeting LINC complex-related vascular disorders. (Figure presented.).