DSpace Angular :: Browsing by Author "Simoons, ML"

Now showing 1 - 2 of 2

Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation
(2000) Alexander, JH; Sparapani, RA; Mahaffey, KW; Deckers, JW; Newby, LK; Ohman, EM; Corbalán, R; Chierchia, SL; Boland, JB; Simoons, ML; Califf, RM; Topol, EJ; Harrington, RA
Context Controversy surrounds the diagnostic and prognostic importance of slightly elevated cardiac markers in patients with acute coronary syndromes without ST-segment elevation.
Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study
(2001) Mahaffey, KW; Harrington, RA; Akkerhuis, M; Kleiman, NS; Berdan, LG; Crenshaw, BS; Tardiff, BE; Granger, CB; DeJong, I; Bhapkar, M; Widimsky, P; Corbalon, R; Lee, KL; Deckers, JW; Simoons, ML; Topol, EJ; Califf, RM
Background Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions (MIs) reported by site investigators in the international Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial and those adjudicated by a central clinical events committee (CEC) to determine the reasons for differences in event rates.