Browsing by Author "Simon, F."
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- ItemAngiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas(2016) Morales, M. G.; Abrigo, J.; Acuña M. J.; Santos, Ra.; Bader, M.; Brandan, Enrique; Simon, F.; Olguín Marín, Hugo César; Cabrera, D.; Cabello Verrugio, Claudio Alejandro
- ItemCholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor(2020) Abrigo, J.; Gonzalez, F.; Aguirre, F.; Tacchi, F.; Gonzalez, A.; Meza, M. P.; Simon, F.; Cabrera García, Daniel Alejandro; Arrese, Marco; Karpen, S.; Cabello Verrugio, Claudio Alejandro
- ItemEndothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions(2017) Kalergis Parra, Alexis Mikes; Pérez, L.; Muñoz, N.; Riedel, C.; Echeverría, C.; Cabello Verrugio, Claudio Alejandro; Simon, F.
- ItemExcess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species(2015) Arriagada, A.; Albornoz, E.; Opazo, M.; Becerra, A.; Vidal G.; Fardella B., Carlos; Michea, L.; Carrasco, N.; Simon, F.; Elorza, A.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Riedel, C.
- ItemGestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis(2018) Haensgen, H.; Albornoz, E.; Opazo, M.; Bugueno, K.; Jara Fernandez, E.; Binzberger, R.; Rivero Castillo, T.; Salas, L.; Simon, F.; Kalergis Parra, Alexis Mikes
- ItemImprinting of maternal thyroid hormones in the offspring.(2017) Opazo, M.; Haensgen, H.; Bohmwald Prieto, Karen; Venegas, L.; Boudin, H.; Elorza, A.; Simon, F.; Fardella B., Carlos; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes; Riedel, C.
- ItemImproved balance between compressive strength and thermal conductivity of insulating and structural lightweight concretes for low rise construction(2020) Remesar Lera, José Carlos; Simon, F.; Vera Araya, Sergio Eduardo; López Casanova, Mauricio Alejandro; CEDEUS (Chile)
- ItemLiquid extracorporeal carbon dioxide removal : use of THAM (tris-hydroxymethyl aminomethane) coupled to hemofiltration to control hypercapnic acidosis in a porcine model of protective mechanical ventilation(2016) Tapia, P.; Lillo, F.; Soto, D.; Escobar, L.; Simon, F.; Hernandez, K.; Alegría Aguirre, Luz Katiushka; Bruhn, Alejandro
- ItemN-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease(2020) Abrigo, J.; Marin, T.; Aguirre, F.; Tacchi, F.; Vilos, C.; Simon, F.; Arrese Jiménez, Marco; Cabrera García, Daniel Alejandro; Cabello Verrugio, Claudio Alejandro
- ItemPhysics at the CLIC e+e- Linear Collider -- Input to the Snowmass process 2013(2013) Abramowicz, H.; Abusleme Hoffman, Angel Christian; Afanaciev, K.; Alexander, G.; Alipour Tehrani, N.; Alonso, O.; Andersen, K.K.; Arfaoui, S.; Balazs, C.; Barklow, T.; Battaglia, M.; Benoit, M.; Bilki, B.; Blaising, J.J.; Boland, M.; Boronat, M.; Bozovic Jelisavcic, I.; Burrows, P.; Chefdeville, M.; Contino, R.; Dannheim, D.; Demarteau, M.; Díaz, Marco A.; Dieguez, A.; Duarte Campderros, J.; Eigen, G.; Elsener, K.; Feldman, D.; Felzmann, U.; Firlej, M.; Firu, E.; Fiutowski, T.; Francis, K.; Gaede, F.; Garcia Garcia, I.; Ghenescu, V.; Giudice, G.; Graf, N.; Grefe, C.; Grojean, C.; Gupta, R.S.; Hauschild, M.; Holmestad, H.; Idzik, M.; Joram, C.; Kananov, S.; Karyotakis, Y.; Killenberg, M.; Klempt, W.; Kraml, S.; Krupa, B.; Kulis, S.; Lastovicka, T.; LeBlanc, G.; Levy, A.; Levy, I.; Linssen, L.; Lucaci Timoce, A.; Lukic, S.; Makarenko, V.; Marshall, J.; Martin, V.; Mikkelsen, R.E.; Milutinovic-Dumbelovic, G.; Miyamoto, A.; Monig, K.; Moortgat-Pick, G.; Moron, J.; Munnich, A.; Neagu, A.; Pandurovic, M.; Pappadopulo, D.; Pawlik, B.; Porod, W.; Poss, S.; Preda, T.; Rassool, R.; Rattazzi, R.; Redford, S.; Reichold, A.; Repond, J.; Riemann, S.; Robson, A.; Roloff, P.; Ros, E.; Rosten, J.; Ruiz-Jimeno, A.; Rzehak, H.; Sailer, A.; Schlatter, D.; Schulte, D.; Sefkow, F.; Seidel, K.; Shumeiko, N.; Sicking, E.; Simon, F.; Smith, J.; Soldner, C.; Stapnes, S.; Strube, J.; Suehara, T.; Swientek, K.; Szalay, M.; Tanabe, T.; Tesar, M.; Thamm, A.; Thomson, M.; Trenado Garcia, J.; Uggerhoj, U.I.; van der Kraaij, E.; Vila, I.; Vilella, E.; Villarejo, M.A.; Vogel González, Marcelo Alonso; Vos, M.; Watson, N.; Weerts, H.; Wells, J.D.; Weuste, L.; Wistisen, T.N.; Wootton, K.; Xia, L.; Zawiejski, L.; Zgura, I.S.This paper summarizes the physics potential of the CLIC high-energy e+e- linear collider. It provides input to the Snowmass 2013 process for the energy-frontier working groups on The Higgs Boson (HE1), Precision Study of Electroweak Interactions (HE2), Fully Understanding the Top Quark (HE3), as well as The Path Beyond the Standard Model -- New Particles, Forces, and Dimensions (HE4). It is accompanied by a paper describing the CLIC accelerator study, submitted to the Frontier Capabilities group of the Snowmass process.
- ItemRole of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia(2018) Abrigo, J.; Elorza, A. A.; Riedel, C. A.; Vilos, C.; Simon, F.; Cabrera García, Daniel Alejandro; Estrada, L.; Cabello Verrugio, Claudio Alejandro
- ItemSarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5(2020) Abrigo, J.; Campos, F.; González, F.; Aguirre, F.; González, A.; Huerta Salgado, C.; Conejeros, S.; Simon, F.; Arrese, Marco; Cabello Verrugio, Claudio Alejandro; Elorza, A. A.; Cabello Verrugio, Claudio Alejandro
- ItemThe role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release(2024) Duarte, Y.; Quintana-Donoso, D.; Moraga-Amaro, R.; Dinamarca, I.; Lemunao, Y.; Cardenas, K.; Bahamonde, T.; Barrientos, T.; Olivares, P.; Navas, C.; Carvajal, F.J.; Santibanez, Y.; Castro-Lazo, R.; Paz Meza, M.; Jorquera, R.; Gomez, G.I.; Henke, M.; Alarcon, R.; Gabriel, L.A.; Schiffmann, S.; Cerpa Nebott, Waldo; Retamal, M.A.; Simon, F.; Linsambarth, S.; Gonzalez-Nilo, F.; Stehberg, J.The role of ventral hippocampus (vHipp) astroglial gliotransmission in depression was studied using chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS) rodent models. CRS increased Cx43 hemichannel activity and extracellular glutamate levels in the vHipp and blocking astroglial Cx43 hemichannel-dependent gliotransmission during CRS prevented the development of depression and glutamate buildup. Moreover, the acute blockade of Cx43 hemichannels induced antidepressant effects in rats previously subjected to CRS or CUMS. This antidepressant effect was prevented by coinjection of glutamate and D-serine. Furthermore, Cx43 hemichannel blockade decreased postsynaptic NMDAR currents in vHipp slices in a glutamate and D-serine-dependent manner. Notably, chronic microinfusion of glutamate and D-serine, L-serine, or the NMDAR agonist NMDA, into the vHipp induced depressive-like symptoms in nonstressed rats. We also identified a small molecule, cacotheline, which blocks Cx43 hemichannels and its systemic administration induced rapid antidepressant effects, preventing stress-induced increases in astroglial Cx43 hemichannel activity and extracellular glutamate in the vHipp, without sedative or locomotor side effects. In conclusion, chronic stress increases Cx43 hemichannel-dependent release of glutamate and D-/L-serine from astrocytes in the vHipp, overactivating postsynaptic NMDARs and triggering depressive-like symptoms. This study highlights the critical role of astroglial gliotransmitter release in chronic stress-induced depression and suggests it can be used as a target for the prevention and treatment of depression.