Browsing by Author "Silva, Macarena"

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    Clinical characteristics and outcomes of people living with HIV hospitalized with COVID-19: a nationwide experience
    (2021) Ceballos, Maria Elena; Ross, Patricio; Lasso, Martin; Dominguez, Isabel; Puente, Marcela; Valenzuela, Pablo; Enberg, Margarita; Serri, Michel; Muñoz, Rodrigo; Pinos, Yazmin; Silva, Macarena; Noguera, Matías; Domínguez, Angélica; Zamora, Francisco; Chilean HIV/COVID-19 Study Group
    In this prospective, multicentric, observational study, we describe the clinical characteristics and outcomes of people living with HIV (PLHIV) requiring hospitalization due to COVID-19 in Chile and compare them with Chilean general population admitted with SARS-CoV-2. Consecutive PLHIV admitted with COVID-19 in 23 hospitals, between 16 April and 23 June 2020, were included. Data of a temporally matched-hospitalized general population were used to compare demography, comorbidities, COVID-19 symptoms, and major outcomes. In total, 36 PLHIV subjects were enrolled; 92% were male and mean age was 44 years. Most patients (83%) were on antiretroviral therapy; mean CD4 count was 557 cells/mm3. Suppressed HIV viremia was found in 68% and 56% had, at least, one comorbidity. Severe COVID-19 occurred in 44.4%, intensive care was required in 22.2%, and five patients died (13.9%). No differences were seen between recovered and deceased patients in CD4 count, HIV viral load, or time since HIV diagnosis. Hypertension and cardiovascular disease were associated with a higher risk of death ( p = 0.02 and 0.006, respectively). Compared with general population, the HIV cohort had significantly more men (OR 0.15; IC 95% 0.07–0.31) and younger age (OR 8.68; IC 95% 2.66–28.31). In PLHIV, we found more intensive care unit admission (OR 2.31; IC 95% 1.05–5.07) but no differences in the need for mechanical ventilation or death. In this cohort of PLHIV hospitalized with COVID-19, hypertension and cardiovascular comorbidities, but not current HIV viro-immunologic status, were the most important risk factors for mortality. No differences were found between PLHIV and general population in the need for mechanical ventilation and death.
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    Psychotherapie aus der Sicht von Klienten mit Schizophrenie
    (2016) Krause Jacob, Mariane; Abarzúa, Marianella; Silva, Macarena; Navarro, Daniela; Altimir Colao, Carolina
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    Psychotherapy from the perspective of Chilean patients with schizophrenia
    (2016) Abarzúa, Marianella; Silva, Macarena; Navarro, Daniela; Krause Jacob, Mariane
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    Reading Comprehension in Children With Specific Language Impairment : an Exploratory Study of Linguistic and Decoding Skills
    (2015) Coloma T., Carmen J.; Silva, Macarena; Palma, Sandra; Holtehuer, Carolina
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    SARS-CoV-2 infection in people living with HIV. Topics on the global panorama and in Chile
    (2022) Silva, Macarena; Blamey, Rodrigo; Ceballos, M. Elena; Araya, Ximena; Bastias, Carla; Twele, Loreto; Munoz, Rodrigo; Sciaraffia, Alicia; Pinera, Cecilia
    The COVID-19 disease is caused by the SARS-CoV-2 virus and was declared a pandemic by the WHO on March 11, 2020. To date, more than 500 million people have been infected and it has caused over 6 million deaths worldwide. People that belong to the most vulnerable risk groups, such as those at the extremes of life, patients with chronic comorbidities and those with severe immunosuppression, are especia-lly susceptible to developing a severe form of COVID-19 infection and death. Subjects living with HIV, especially those in precarious immunological conditions or those in whom antiretroviral therapy is yet to be started, may be at risk of developing complications related to COVID-19, as observed with other infectious diseases. This review aims to determine the magnitude of the impact of the SARS-CoV-2 virus on people living with HIV in Chile.