Browsing by Author "Sepulveda, Rolando"
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- ItemExtracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells(2020) Hernandez, Alejandra; Reyes, Daniela; Geng, Yana; Pablo Arab, Juan; Cabrera, Daniel; Sepulveda, Rolando; Solis, Nancy; Buist-Homan, Manon; Arrese, Marco; Moshage, HanBackground: The transition from steatosis to non-alcoholic steatohepatitis (NASH) is a key issue in non-alcoholic fatty liver disease (NAFLD). Observations in patients with obstructive sleep apnea syndrome (OSAS) suggest that hypoxia contributes to progression to NASH and liver fibrosis, and the release of extracellular vesicles (EVs) by injured hepatocytes has been implicated in NAFLD progression.