Browsing by Author "Scheffler, S."

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    Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta 1i), MECL1 (beta 2i) and LMP7 (beta 5i)
    (OXFORD UNIV PRESS, 2008) Scheffler, S.; Kuckelkorn, U.; Egerer, K.; Doerner, T.; Reiter, K.; Soza, A.; Burmester, G. R.; Feist, E.
    Objectives. Autoantibodies against the 20S-proteasome display a broad diversity with a remarkably low frequency of individual cross-reactivity against the different subunits of the proteasome. Although their pathogenic and diagnostic significance remains obscure, an involvement in the clearance of circulating proteasomes as well as an interaction with the activity of the proteolytic complex was assumed in previous studies.