Browsing by Author "Sarria, Edgar E."

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    Postinfectious bronchiolitis obliterans in children: The South American contribution
    (2014) Castro Rodríguez, José Antonio; Giubergia, Veronica; Fischer, Gilberto B.; Castaños, Claudio; Sarria, Edgar E.; González, Ramiro; Mattiello, Rita; Vega-Briceño, Luis E.; Murtagh, Patricia
    Postinfectious bronchiolitis obliterans (PIBO) is an infrequent chronic lung that causesirreversible obstruction and, or, obliteration of the smaller airways. This review particularlyfocuses on more than 30 studies from South America.Conclusion: The initial PIBO event occurs in the early years of life and is strongly associatedwith adenovirus infection and the need for mechanical ventilator support. Treatmentrequires a multidisciplinary strategy. Multicentre studies are needed to determineprogression, optimal management and long-term follow-up.
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    The wheezy infant: A viewpoint from low-middle income countries
    (W.B. Saunders Ltd, 2022) Mocelin, Helena Teresinha; Fischer Bueno, Gilberto; da Silva Filho, Luiz Vicente Ribeiro Ferreira; Castro Rodríguez, José Antonio; Sarria, Edgar E.
    To review the recent evidence in the literature of various aspects of recurrent/severe wheezing in children under 3 in low-middle income countries [LMICS]. Sources: A non-systematic review including articles in English. We mainly selected publications from the last 5 years. Studies on epidemiology, aetiology, diagnosis, treatment, and prevention were included in the search. We reviewed differential diagnoses of wheezing that focused on LMICS. We also reviewed aspects of prevention. Summary of the findings: Many epidemiological studies have shown a variable but significant number of wheezy infants [WI] cases in LMICS when compared to other countries. The differential diagnosis of causes of wheezing in this age group is mandatory, taking into account local facilities. Few treatment options have been well studied for this age group. In LMICS, a pragmatic approach could be considered, as described in the article. It is difficult to study primary prevention for WI and secondary prevention (mainly environmental) may have some impact. A schematic approach for recurrent wheezers is presented, which takes into account settings with limited resources. Conclusion: Severely or recurrently wheezy children under 3 is a common clinical issue in LMICS. Studies on this age group are needed to reduce the significant morbidity. It may be possible to lower the high burden of wheezing in this age group by selecting the phenotype which may respond to inhaled steroids.