Browsing by Author "Sanchez-Montalva, Adrian"

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    Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
    (2021) Perez-Recio, Sandra; Pallares, Natalia; Grijota-Camino, Maria D.; Sanchez-Montalva, Adrian; Barcia, Laura; Campos-Gutierrez, Silvia; Pomar, Virginia; Rabunal-Rey, Ramon; Balcells, Maria Elvira; Gazel, Deniz; Montiel, Natalia; Vicente, Diego; Goic-Barisic, Ivana; Schon, Thomas; Paues, Jakob; Marekovic, Ivana; Cacho-Calvo, Juana; Barac, Aleksandra; Goletti, Delia; Garcia-Gasalla, Mercedes; Maria Barcala, Jose; Teresa Tortola, Maria; Anibarro, Luis; Suarez-Toste, Isabel; Moga, Esther; Gude-Gonzalez, Maria J.; Naves, Rodrigo; Karsligil, Tekin; Martin-Penaranda, Tania; Stevanovic, Goran; Trigo, Matilde; Rubio, Veronica; Karaoglan, Ilkay; Bayram, Nazan; Alcaide, Fernando; Tebe, Cristian; Santin, Miguel
    We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value.0.6 IU.ml(-1) was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU.ml(-1) and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of.0.6 IU.ml(-1) was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.