Browsing by Author "San Martin, Aurelio"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    An unusual mulinane diterpenoid from the Chilean plant Azorella trifurcata (Gaertn) Pers
    (2014) Areche, Carlos; Sepulveda, Beatriz; San Martin, Aurelio; Garcia-Beltran, Olimpo; Simirgiotis, Mario; Canete, Alvaro
    Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13 alpha-hydroxyazorellane, 13 beta-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7 alpha-acetoxy-9-epi-13 beta-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55mg kg(-1)). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model.