Browsing by Author "Salazar-Ardiles, Camila"

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    Cardiorespiratory optimal point as a submaximal evaluation tool in endurance athletes: An exploratory study
    (2023) Oyarzo-Aravena, Alexis; Arce-Alvarez, Alexis; Salazar-Ardiles, Camila; Ramirez-Campillo, Rodrigo; Alvarez, Cristian; Toledo, Camilo; Izquierdo, Mikel; Andrade, David C.
    Introduction: The cardiorespiratory optimal point (COP) represents the lowest minute ventilation to oxygen consumption ratio (VE/VO2) and can be estimated during a CPET at submaximal intensity when an exercise test until volitional fatigue is not always advisable (i.e., a conflict zone where you cannot be confident of the security because near-competition, off-season, among other). COP's physiological components have not been wholly described yet. Therefore, this study seeks to identify the determinants of COP in highly trained athletes and its influence on maximum and sub-maximum variables during CPET through principal c omponent analysis (PCA) (explains the dataset's variance).Methods: Female (n = 9; age, 17.4 +/- 3.1 y; maximal VO2 [VO2max]), 46.2 +/- 5.9 mL/kg/min) and male (n = 24; age, 19.7 +/- 4.0 y; VO2max, 56.1 +/- 7.6 mL/kg/min) athletes performed a CPET to determine the COP, ventilatory threshold 1 (VT1) and 2 (VT2), and VO2max. The PCA was used to determine the relationship between variables and COP, explaining their variance.Results: Our data revealed that females and males displayed different COP values. Indeed, males showed a significant diminished COP compared to the female group (22.6 +/- 2.9 vs. 27.2 +/- 3.4 VE/VO2, respectively); nevertheless, COP was allocated before VT1 in both groups.Discussion: PC analysis revealed that the COP variance was mainly explained (75.6%) by PC1 (expired CO2 at VO2max) and PC2 (VE at VT2), possibly influencing cardiorespiratory efficiency at VO2max and VT2. Our data suggest that COP could be used as a submaximal index to monitor and assess cardiorespiratory system efficiency in endurance athletes. The COP could be particularly useful during the offseason and competitive periods and the return to the sports continuum.
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    Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats
    (2024) Salazar-Ardiles, Camila; Cornejo, Carlos; Paz, Cristobal; Vasquez-Muñoz, Manuel; Arce-Alvarez, Alexis; Rodríguez Fernández, María; Millet, Gregoire P.; Izquierdo Redín, Mikel; Andrade, David C.
    Background Outstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude hypobaric-hypoxia (HH), there is a baroreflex-dependent parasympathetic withdrawal and exercise performance deterioration. Notably, vagal control is pivotal in exercise performance, and exogenous oxytocin (OXY) administration has been shown to enhance parasympathetic drive; however, no evidence shows their role in exercise performance during HH. Then, this study aimed to examine the effect of prolonged exogenous oxytocin (OXY) administration on exercise performance during hypobaric hypoxia (HH) in rats. Results A vehicle group (n = 6) and an OXY group (n = 6) performed incremental exercise and baroreflex tests during both normobaric normoxia (NN) and HH (PO2: 100 mmHg, simulated 3,500 m) prior (pre-) and after (post-) 14 days of administration. The results showed that at pre-, there were no significant differences in exercise performance between the two groups, while at post-, the OXY group exhibited similar performance between NN and HH, while the Vehicle group maintained a significant decline in performance at HH compared to NN. At post-, the Vehicle group also demonstrated a reset in the baroreflex and a worse bradycardic response in HH, which was reversed in the OXY group, while the hypoxic ventilatory response was similar in both groups. Conclusion The findings suggest prolonged OXY administration prevents impaired exercise performance and vagal control during short-term HH.