Browsing by Author "SOZA, MA"

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    CHANGES IN CONTRALATERAL SYNAPTIC ACETYLCHOLINESTERASE FOLLOWING MOTOR-NERVE SECTION IN RATS
    (1988) FADIC, R; SOZA, MA; INESTROSA, NC
    We report here that denervation of rat extensor digitorum longus, soleus and diaphragm muscle results in an increase of a subset of asymmetric acetylcholinesterase (class II A-forms) in the contralateral muscle, within a few days. This observation is interesting because it suggests a specific regulation of one asymmetric enzyme fraction, which is solubilized only in the presence of chelating agents and is thought to reside in the basal lamina.
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    INCREASE OF MUSCLE PEROXISOMAL ENZYMES AND MYOTONIA INDUCED BY NAFENOPIN, A HYPOLIPIDEMIC DRUG
    (1983) BEHRENS, MI; SOZA, MA; INESTROSA, NC
    The chronic administration of nafenopin, a hypolipidemic drug, induced an increase in catalase and acyl-CoA oxidase activities in various rat skeletal muscles, including the gracilis, diaphragm, soleus and extensor digitorum longus. The magnitude of the increase was around 100% for both enzymes in each of the muscles studied in spite of the different basal level. These changes seem to be specific of the peroxisomal enzymes because acetylcholinesterase, which is not peroxisomal, did not follow the same pattern in all the muscles. Concomitant with the increase in muscle peroxisomal enzymes, the skeletal muscles presented an altered electromyogram with prolonged insertional activity, repetitive firing of action potentials and myotonic runs characteristic of myotonia. A role for peroxisomes in the myotonic disorder is suggested.