Browsing by Author "SOTO, ME"

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    ANTIHYPERTENSIVE AND HORMONAL EFFECTS OF SINGLE ORAL DOSES OF CAPTOPRIL AND NIFEDIPINE IN ESSENTIAL-HYPERTENSION
    (1981) SOTO, ME; THIBONNIER, M; SIRE, O; MENARD, J; CORVOL, P; MILLIEZ, P
    In a single-dose crossover study captopril (SQ 14225), 1 mg/kg body wt, and nifedipine (Bay-a 1040) 20 mg were administered orally to 12 hospitalized patients with essential hypertension (stage 1 or 2, WHO). Both drugs significantly reduced blood pressure, but each dose acted differently: the mean maximum arterial pressure reduction was faster and greater with nifedipine than with captopril: -23 .+-. 2% at 37 .+-. 15 min and -17 .+-. 1% at 86 .+-. 25 min, respectively. Captopril inhibited angiotensin II and aldosterone production, but did not accelerate heart rate or stimulate vasopressin release. Nifedipine stimulated vasopressin release and increased heart rate, but the renin-angiotensin-aldosterone system was not significantly affected. The blood pressure reduction was related to the initial level of activation of the renin-angiotensin system only for captopril. The blood pressure reduction induced by 1 drug was not related to that produced by the other in the same patient.
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    EFFECTS OF NIFEDIPINE DURING LOW, NORMAL AND HIGH INTAKES OF SODIUM IN PATIENTS WITH ESSENTIAL-HYPERTENSION
    (1982) VALDES, G; SOTO, ME; CROXATTO, HR; BELLOLIO, T; CORBALAN, R; CASANEGRA, P