Browsing by Author "Rumie, H"

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    Accidental clozapine intoxication in a ten-year-old child
    (2003) Borzutzky, A; Avello, E; Rumie, H; Paris, E
    Clozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. Severe side effects of overdose have been described in children. This report describes the unintentional ingestion of clozapine by a 10-y-o girl, presenting dramatic changes of mental status and progressive alteration of consciousness with a Glasgow Coma Scale drop from 12 to 7. Urine analysis revealed 500 mug clozapine/L 24 h after ingestion. Full resolution of symptoms occurred after approximated 55 h with no sequels or alterations at follow-up. Awareness must be taken when administering atypical antipsychotics such as clozapine to children because of the severe intoxication effects cases reported.
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    Y chromosome sequences in Turner's syndrome: Association with virilization and gonadoblastoma
    (FREUND PUBLISHING HOUSE LTD, 2003) Mancilla, EE; Poggi, H; Repetto, G; Rumie, H; Garcia, H; Ugarte, F; Hidalgo, S; Jara, A; Muzzo, S; Panteon, E; Torrealba, I; Foradori, A; Cattani, A
    The presence of Y chromosome fragments in patients with Turner's syndrome is known to increase the risk of gonadoblastoma and virilization. Y chromosome material is detected in up to 6% of patients with Turner's syndrome by karyotype. By DNA analysis, Y chromosome sequences have been reported in 0-60% of patients. The putative gonadoblastoma gene has been mapped to the pericentromeric region of the Y chromosome increasing the interest in studying these sequences.